侵袭性伪足和MMP-14在肿瘤发病机制中的研究进展

恶性肿瘤仍是目前医学难以攻克的课题,原发肿瘤是否已经发生转移,直接影响肿瘤患者的预后。基质金属蛋白酶14(MMP-14)参与正常细胞的生理功能和肿瘤相关过程,如细胞迁移、炎症、侵袭、转移、血管生成和扩散。侵袭性伪足是恶性肿瘤细胞膜形成的一种向外凸起的、具有降解细胞外基质(ECM)能力的膜型突起结构。两者在肿瘤的发生发展中具有重要作用。

Progress in the research on the roles of invadopodia and metalloproteinase-14 in tumorigenesis and cancer development

Malignant tumors are still enigmatic in the field of medical science. The prognosis of cancer patients largely depends on whether the primary tumor has metastasized or not. Matrix metalloproteinase-14(MMP-14)is involved in physiological functions of normal cells and in tumor-related processes, such as cell migration, inflammation, invasion, metastasis, and angiogenesis. Invadopodia are protrusions of the plasma membranes of malignant tumor cells, with the ability to degrade the extracellular matrix. Thus, MMP-14 and invadopodia have critical roles in tumorigenesis and cancer progression.