子痫前期并发胎儿生长受限的临床特征及妊娠结局分析

目的 探讨子痫前期并发胎儿生长受限(fetal growth restriction,FGR)的临床特征及母儿结局.方法 回顾性分析2009年1月1日至2019年12月31日在广州医科大学附属第三医院产科就诊并分娩的单胎子痫前期患者的病例资料,根据是否合并FGR,分为FGR组和对照组,分析两组的临床特征及母儿结局.结果...

Clinical characteristics and pregnancy outcomes of preeclampsia complicated with fetal growth restriction

ObjectiveTo investigate the clinical features and maternal and neonatal outcomes of preeclampsia complicated with fetal growth restriction (FGR). MethodsThe clinical data of patients with preeclampsia, who were admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 1, 2009 to December 31, 2019, were retrospectively analyzed. According to whether they were complicated with FGR, they were divided into FGR group and control group. The clinical characteristics and maternal and neonatal outcomes of two groups were analyzed. Results(1) The incidence of FGR in 2960 cases of preeclampsia was 20.68%. The incidences of FGR in early-onset and late-onset preeclampsia were 30.3% and 13.7%, respectively (P<0.05). (2) There were significant differences in educational level, gravidity, mode of conception and type of admission between the two groups (all P<0.05). (3) In FGR group, the gestational age of live birth (33.44±3.13) was significantly less than that in control group (35.82±3.78), the stillbirth rate (15.03%), cesarean section rate (80.39%) and hospital stay [(9.21±4.70)d] were significantly higher than those in control group [10.78%, 71.12%, 8.45±6.34 (d)], the incidences of fetal distress (24.18%) and oligohydramnios (13.89%) in FGR group were significantly higher than those in control group (10.09% and 6.39%) (P<0.05). (4) The results showed that the average weight, length and head circumference of newborns in FGR group were lower than those in control group. The incidence of neonatal asphyxia (21.0%), neonatal respiratory distress (18.65%), pulmonary hyaline membrane disease (4.62%) and neonatal anemia (17.69%) in FGR group were significantly higher than those in control group (14.1%, 10.60%, 2.82% and 7.97%), the differences were statistically significant (P<0.05). ConclusionsPreeclampsia is closely related to the occurrence of FGR. Preeclampsia patients complicated with FGR have an increased risk of adverse maternal and neonatal outcomes.