前列腺穿刺活检单针阳性患者行前列腺根治性切除术后的病理特征

目的 研究前列腺穿刺活检单针阳性患者行前列腺根治性切除术(RP)后的病理特征。方法 选择本院于2017年9月至2018年10月收入的前列腺癌(PCa)患者85例，均为前列腺穿刺活检单针阳性，对相关临床资料进行分析，根据术前因素进行分组，观察临床病理差异。结果 不同年龄段患者术后各项病理特征差异无统计学意义，在不同前列腺特异抗原（PSA）上pT0期、切缘阳性、病理分期＞T2比较，差异无统计学意义（P＞0.05），在不同临床分期上pT0期、切缘阳性、病理分期＞T2比较，差异无统计学意义（P＞0.05）；PSA≥10 ng/mL患者在Gleason≥7分比例上明显多于PSA＜10 ng/mL患者，临床分期cT1患者在pT0期上多于cT2患者，差异有统计学意义（P＜0.05）。在穿刺Gleason评分上pT0期、切缘阳性、Gleason≥7分比较，差异无统计学意义（P＞0.05）；但Gleason 4+3分患者病理分期＞T2高于6分、3+4分、≥8分患者，差异有统计学意义（P＜0.05）。 结论 前列腺穿刺活检单针阳性不可作为PCa低风险筛查指标，大多数单针阳性患者需要积极进行治疗。

Pathological characteristics of patients with positive single needle aspiration biopsy after radical prostatectomy

Objective  To study the pathological characteristics of patients with positive single needle aspiration biopsy after radical prostatectomy.Methods  From September 2017 to October 2018, 85 patients with prostate cancer admitted to our hospital were selected. All patients underwent prostate biopsy with positive single needle. Relevant clinical data were analyzed and grouped according to preoperative factors to observe the clinicopathological differences. Results  There was no difference in the pathological characteristics of the patients in different age groups and there was no difference in pT0 stage, incision margin positive stage,pathological stage>T2 on different PSA.There was no difference in pT0 stage,incision margin positive stage,pathological stage>T2 on different clinical stages(P>0.05).The proportion of Gleason≥7 in patients with PSA≥10 ng/mL was significantly higher than that in patients with PSA<10 ng/mL,and that in patients with clinical stage cT1 in pT0 stage was significantly higher than that in patients with cT2(P<0.05).There was no difference in pT0,positive incision margin and Gleason≥7 on the Gleason score(P>0.05),but the pathological stage of patients with 4+3 score was higher than 6, 3+4 and≥8,with significant difference(P<0.05).Conclusions  Single needle positive prostate biopsy can not be used as a low risk screening index for prostate cancer.Most single needle positive patients need active treatment,which is conducive to improving the prognosis of patients and is worth applying.