乳腺粘液腺癌的临床病理特征及预后分析 |
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引用本文: | 高婷,黄胜,郭瑢,陈德滇. 乳腺粘液腺癌的临床病理特征及预后分析[J]. 昆明医科大学学报, 2023, 44(3): 54-60. DOI: 10.12259/j.issn.2095-610X.S20230306 |
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作者姓名: | 高婷 黄胜 郭瑢 陈德滇 |
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作者单位: | 昆明医科大学第三附属医院/云南省肿瘤医院乳腺外二科,云南 昆明 650118 |
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基金项目: | 国家自然科学基金资助项目(81860465) |
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摘 要: | 目的 探讨乳腺粘液腺癌(mucinous breast carcinoma,MuBC)的临床病理特征及其与预后的关系,为患者个性化治疗方案的制订提供参考。方法 回顾性收集2008年1月至2021年9月云南省肿瘤医院收治的139例MuBC患者的临床及病理资料,将其分为76例单纯型粘液腺癌(pure mucinous breast carcinoma,PMuBC)组和63例混合型粘液腺癌(mixed mucinous breast carcinoma,MMuBC)组并进行比较。采用COX比例风险回归模型确定MuBC的预后因素,Kaplan-Meier法和log-rank检验用于生存分析。结果 PMuBC组的10 a总生存率较MMuBC组高(98.6%vs 83.7%,P=0.019)。PMuBC组淋巴结未受累的比例(81.6%vs 47.6%,P <0.001)高于MMuBC组。COX多因素分析显示:肿瘤大小为T1期(P=0.005)、肿瘤大小为T2期(P=0.006)和PR阳性(P=0.033)是预后的保护因素。淋巴结受累达N3期(P=0.052)与合并远处转移(P=0.025)是...
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关 键 词: | 乳腺粘液腺癌 病理特征 预后 生存 |
收稿时间: | 2022-11-14 |
Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma |
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Affiliation: | The Second Department of Breast Surgery,The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan,Kunming Yunnan 650118,China |
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Abstract: | Objective To investigate the clinicopathological characteristics of mucinous breast carcinoma (MuBC) and its relationship with prognosis, so as to provide reference for patients to make a personalized treatment plan. Methods The clinical and pathological data of 139 MuBC patients admitted to Yunnan Cancer Hospital from January 2008 to September 2021 were retrospectively collected. They were divided into pure mucinous breast carcinoma (PMuBC) group (n = 76) and mixed mucinous breast carcinoma (MMuBC) group (n = 63), and compared between two groups. COX proportional hazards regression model was used to determine the prognostic factors of MuBC.Kaplan-Meier and log-rank tests were used for survival analysis. Results The 10-year overall survival rate of PMuBC group was higher than that of MMuBC group (98.6% vs 83.7%, P = 0.019). The proportion of uninvolved lymph nodes (81.6% vs 47.6%, P < 0.001) in PMuBC group was higher than those in MMuBC group.COX multivariate analysis showed that tumor size was stage T1 (P = 0.005), tumor size was stage T2 (P = 0.006) and positive PR (P = 0.033) were prognostic protective factors. Lymph node involvement reached stage N3 (P = 0.052) and distant metastasis (P = 0.025) are prognostic risk factors. Conclusions Tumor size, lymph node metastasis, distant metastasis and PR status are independent prognostic factors for MuBC. Compared with MMuBC, PMuBC has lower lymph node metastasis rate, higher positive rate of PR and better prognosis. |
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