支气管哮喘患者血清miR-155、HP及MPO水平与肺功能的关系

 目的 探讨支气管哮喘患者血清miR-155、HP及MPO水平与肺功能的关系。方法 选择2017-11至2019-09医院呼吸内科收治的支气管哮喘患者62例,其中39例处于发作期作为发作组,23例处于缓解期作为缓解组,另选择同期健康体检者12例作为健康组,对各组受试人员血清微小RNA-155 ( miR-155)、羟脯氨酸(HP)及髓过氧化物酶(MPO)水平与肺功能进行检测并对比分析。结果 发作组和缓解组HP、MPO、miR-155表达水平均明显高于健康组(均P<0.01),发作组HP(mg/L)、MPO(U/L)、miR-155表达水平明显高于缓解组(1.97±0.98 vs 1.49±0.73、757.28±111.63 vs 579.06±101.74、2.89±0.93 vs 2.02±0.83,均P<0.01);发作组和缓解组FVC、FEV₁、FEV₁/FVC、MMEF_75/25、PEF指标均明显低于健康组(均P<0.01),发作组FVC(L)、FEV₁(L)、FEV₁/FVC(%)、MMEF_75/25(L/s)、PEF(L/min)指标明显低于缓解组(2.63±0.92 vs 3.12±0.76、1.45±0.31 vs 1.87±0.30、59.26±14.25 vs 73.73±10.04、0.41±0.09 vs 0.73±0.08、138.95±15.06 vs 402.69±10.85,均P<0.01);FVC、FEV₁、FEV₁/FVC、MMEF_75/25、PEF与HP、MPO、miR-155均呈负相关性(P<0.05)。结论 支气管哮喘患者血清miR-155、HP及MPO水平均与肺功能有明显的负相关性。

Relationships between serum miR-155, HP and MPO levels and lung function in patients with bronchial asthma

Objective To investigate the correlations between serum miR-155, HP and MPO levels and lung function in patients with bronchial asthma. Methods Sixty-two cases of bronchial asthma treated between November 2017 and September 2019 in our department were selected, 39 of whom were in the onset stage (the onset group), 23 were in the remission stage (the remission group), and another 12 health examinees were enrolled as the healthy group. The levels of serum miR-155(microRNA-155), HP (hydroxyproline) and MPO (myeloperoxidase) were measured and compared between the participants. Results The expressions of HP, MPO and miR-155 in the onset group were significantly higher than those in the healthy group (P<0.01) , and those of the remission group were significantly higher than in the healthy group (P< 0.01) The expressions of HP(mg/L), MPO(U/L)and miR-155 in the onset group were significantly higher than those of the remission group (1.97±0.98 vs 1.49±0.73, 757.28±111.63 vs 579.06±101.74, 2.89±0.93 vs 2.02±0.83,P<0.01). FVC, FEV₁, FEV₁/FVC, MMEF75/25, PEF in the onset group and remission group were significantly lower than those in the healthy group (P< 0.01), and those in the remission group were significantly lower than in the healthy group (P< 0.01). FVC(L), FEV₁(L), FEV₁/FVC(%), MMEF75/25(L/s), PEF(L/min) were significantly lower in the onset group than in the remission group (2.63±0.92 vs 3.12±0.76, 1.45±0.31 vs 1.87±0.30, 59.26±14.25 vs 73.73±10.04,0.41±0.09 vs 0.73±0.08, 138.95±15.06 vs 402.69±10.85,P<0.01). FVC, FEV₁, FEV₁/FVC, MMEF75/25, PEF were negatively correlated with HP, MPO and miR-155(P< 0.05). Conclusions The serum miR-155, HP and MPO levels of bronchial asthma are negatively correlated with lung function.