不同BMI阻塞性睡眠呼吸暂停低通气综合征患儿临床表现及睡眠结构比较

目的 比较分析不同体质量指数(body mass index,BMI)的阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患儿临床表现及睡眠结构.方法 收集2016年12月-2021年2月到苏州大学附属儿童医院呼吸科就诊,完善了多导睡眠监测(...

Comparative Study of Clinical Manifestations and Sleep Structure in Children with Obstructive Sleep Apnea-hypopnea Syndrome with Different BMI

  Objective  To compare and analyze the clinical manifestations and sleep structure of children with obstructive sleep apnea-hypopneasyndrome (OSAHS) with different body mass index (BMI).  Methods  452 children who were diagnosed with OSAHS between December 2016 and February 2021 by the Department of Respiratory Medicine, Children’s Hospital of Soochow University were included in the study. All of them did polysomnography (PSG). They were divided, according to their BMI, into the normal BMI group, the overweight group, and the obesity group. Their clinical data and PSG results were collected.  Results  287 boys (63.5%) and 165 girls (36.5%) were enrolled, with their age ranging between 3 and 15, and the median age being 5.5 (4.5, 7.0). Their BMI ranged between 12.09 kg/m2 and 38.48 kg/m2, with the median being 16.29 kg/m2. 275 cases (60.8%) had normal BMI, 76 cases (16.8%) were overweight, and 101 cases (22.3%) were obese. There was no significant difference in the distribution of clinical manifestations and severity of OSAHS among the three groups. The duration and proportion of rapid eye movement (REM) stage sleep in the obese group was lower than that of the overweight and the normal BMI groups (P<0.05). The lowest oxyhemoglobin saturation (LSaO₂) of children in the overweight group was lower than that of the normal BMI group (P=0.050). The oxygen desaturation index (ODI) of the obese group was higher than that of the normal BMI and the overweight groups (P<0.05).  Conclusion  Obesity worsens the degree of hypoxia in children with OSAHS and affects their sleep structure.