Comparison between Targeted Radionuclide Therapy of Bone Metastases Based on β-Emitting and α-Emitting Radionuclides |
| |
| Affiliation: | 1. Associate Professor, Department of Oral and Maxillofacial–Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China;2. Resident, Department of Oral and Maxillofacial–Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China;3. Professor, Department of Oral and Maxillofacial–Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China;4. Chief Physician, Department of Oral and Maxillofacial–Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China;6. Professor, Department of Oral and Maxillofacial–Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China;1. Medical Physics and Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;2. Medical Students Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |
| |
| Abstract: | IntroductionThe α- and β-emitter radionuclides are used for palliative treatment of bone metastasis. Our objective was to compare the dosimetric parameters of radionuclides used in bone pain palliation therapy.MethodsMonte Carlo code, MCNPX, was used to simulate radiation transport. Dosimetric calculations were performed for monoenergetic electrons with energies of 0.1–3 MeV, α-particles with energies of 3–10 MeV, and several radionuclides 32P, 89Sr, 153Sm, 177Lu, 223Ra, and its progeny. The simulated phantom consisted of bone marrow, an endosteal layer, bone, and soft tissue. Source tissues included bone marrow, endosteal layer, and bone. Absorbed fractions and specific absorbed fractions were calculated for target regions. Absorbed doses were calculated for investigated radionuclides.ResultsThe obtained results demonstrated that the dosimetric parameters vary depending on the source or target size, particle energy, and location of the source. The β-emitter radionuclides were able to penetrate the bone marrow region, whereas the α-emitter radionuclides gave a higher and localized dose to the bone and endosteal layer in comparison.Conclusion223Ra and 177Lu have fewer side effects on the bone marrow, and they may be a better choice for use in bone pain palliation radiotherapy. |
| |
| Keywords: | Bone metastases radionuclide therapy dosimetry β-emitters |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
