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| 无创胎儿DNA检测假阳性对产前诊断的影响分析 | |
| 引用本文： | 刘小霞,王杰,武丽琼,郭志远,张丽春,王晓华,贾跃旗. 无创胎儿DNA检测假阳性对产前诊断的影响分析[J]. 包头医学院学报, 2023, 39(1): 91-96. DOI: 10.16833/j.cnki.jbmc.2023.01.017 |
| 作者姓名： | 刘小霞 王杰 武丽琼 郭志远 张丽春 王晓华 贾跃旗 |
| 作者单位： | 1.内蒙古科技大学包头医学院,内蒙古包头 014040; 2.内蒙古自治区妇幼保健院遗传优生科 |
| 基金项目： | *内蒙古自然科学基金(2019MS08006) |
| 摘 要： | 无创胎儿DNA检测(non-invasive prenatal testing, NIPT)假阳性是导致增加额外的产前诊断和孕妇依从性降低的重要原因，还可能带来非必要的引产。本文就无创胎儿DNA检测假阳性对产前诊断的影响分析进行综述，通过分析NIPT假阳性的原因，在临床应用中结合不同孕妇的个体情况，为个体化、规范化的产前诊断提供指导和理论依据。 |
| 关 键 词： | 无创胎儿DNA检测 假阳性 产前诊断 |
| 收稿时间： | 2022-07-14 |
Effect of false positive in non-invasive DNA detection on prenatal diagnosis |
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| LIU Xiaoxia,WANG Jie,WU Liqiong,GUO Zhiyuan,ZHANG Lichun,WANG Xiaohua,JIA Yueqi. Effect of false positive in non-invasive DNA detection on prenatal diagnosis[J]. Journal of Baotou Medical College, 2023, 39(1): 91-96. DOI: 10.16833/j.cnki.jbmc.2023.01.017 | |
| Authors: | LIU Xiaoxia WANG Jie WU Liqiong GUO Zhiyuan ZHANG Lichun WANG Xiaohua JIA Yueqi |
| Affiliation: | 1. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China; 2. Genetic Eugenic Department of Inner Mongolia Maternity and Child Health Care Hospital |
| Abstract: | False positive non-invasive DNA testing (NIPT) is an important cause of additional prenatal diagnosis and decreased compliance of pregnant women, and can also lead to the unnecessary induction of labor. This paper reviews the analysis of the influence of false positive non-invasive fetal DNA test on prenatal diagnosis, and provides guidance and theoretical basis for individualized and standardized prenatal diagnosis by analyzing the causes of false positive detection of NIPT and combining the individual situation of different pregnant women in clinical application. |
| Keywords: | Non-invasive DNA testing False positive Prenatal diagnosis |
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