胆汁酸在胆汁淤积性肝损伤发病中的作用研究进展

胆汁酸由肝脏产生,是胆汁的主要成分之一。在胆汁分泌受阻时,血清和肝脏胆汁酸浓度上升,进而导致肝损害。尽管过去对于胆汁酸导致肝损害有过很多研究,但是其导致肝损害的分子机制目前仍存在争议。在本文中,我们总结了胆汁酸导致肝损伤发病机制的最新研究进展。在病理条件下,胆汁酸诱导肝细胞损害是通过处于应激条件下的肝细胞诱导炎症反应而发生的。本文主要聚焦胆汁酸如何诱导炎症因子的产生从而进一步诱导相关免疫细胞的聚集,以及基于对这些病理基础的认识,他们探讨了可能对胆汁淤积性肝损害有潜在治疗的新方法。

Role of bile acids in cholestatic liver injury

Objective Bile acid(BA) is synthesized in the liver and is the major component of bile. BAs accumulates in serum and liver when BAs secretion is impaired, which is followed by liver injury. The molecular mechanism of cholestasis has been extensively studied, however, it remains controversial. Recent studies showed that BAs might induce hepatocyte injury under pathological conditions, and the mechanism involved inflammatory response induced by stressed hepatocytes. In this article, we reviewed recent advances in the pathogenesis of liver injury induced by BAs and we focused on how BAs induce the activation of inflammatory cytokines that further induce the aggregation of immune cells. Based on these pathogenesis, we tentatively point out a number of novel treatments for cholestatic liver damage.