特布他林联合多索茶碱对慢性阻塞性肺疾病患者的疗效及患者呼吸动力学的影响

目的:探讨特布他林联合多索茶碱对慢性阻塞性肺疾病患者的疗效及患者呼吸动力学的影响。方法:以随机抽样法选取2018年1月至12月于开滦总医院就诊的86例慢性阻塞性肺疾病(COPD)患者为研究对象,按双盲法分为观察组和对照组,各43例。对照组给予多索茶碱治疗,观察组在上述基础上联合使用特布他林,对比2组疗效、呼吸动力学变化以及肺功能指标和不良反应变化情况。结果:2组治疗前肺动态顺应性、肺静态顺应性和呼吸系统顺应性指标变化对比无显著性差异(P>0.05);2组治疗后各指标均明显改善且观察组改善效果优于对照组(P<0.05);2组治疗前肺功能指标对比无显著性差异(P>0.05);2组治疗后呼气峰流速(PEF)、一秒钟用力呼气容积(FEV1)、FEV1/FVC均有所改善且观察组改善效果更好(P<0.05);观察组治疗总有效率明显高于对照组(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:在COPD患者中给予特布他林联合多索茶碱治疗不仅可以改善患者呼吸动力学以及肺功能,还能提高临床治疗有效率,减少不良反应发生,值得临床推广。

Effect of terbutaline combined with doxofylline on patients with chronic obstructive pulmonary disease and respiratory dynamics

OBJECTIVE To investigate the effect of terbutaline combined with doxofylline on patients with chronic obstructive pulmonary disease and their respiratory dynamics.METHODS Eighty-six patients with chronic obstructive pulmonary disease (COPD) who were admitted to our hospital from January 2018 to December 2018 were randomly selected as subjects. They were divided into observation group and control group according to double-blind method. The control group was treated with doxofylline. The observation group was combined with terbutaline on the above basis to compare the effects of the two groups on the efficacy, respiratory dynamics and changes in lung function.RESULTS There was no significant difference in the changes of lung dynamic compliance, lung static compliance and respiratory compliance before treatment (P>0.05). After treatment, the indexes of the two groups were significantly improved and the improvement effect of the observation group was better than that of the control group (P<0.05); There was no significant difference in the lung function indexes between the two groups before treatment (P>0.05). PEF, FEV1, FEV1/FVC were improved after treatment and the improvement effect of the observation group was better (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).CONCLUSION Terbutaline combined with doxofylline in patients with COPD can not only improve the patient's respiratory dynamics and lung function, but also improve the efficiency of clinical treatment. It is of great significance for promoting the rehabilitation of patients, and it is worthy of clinical application.