不同剂量的罗哌卡因混合舒芬太尼用于剖宫产术等比重蛛网膜下腔阻滞的效果分析

目的探究不同剂量罗哌卡因联合舒芬太尼等比重蛛网膜下腔阻滞在剖宫产手术的麻醉效果。方法选取足月剖宫产产妇80例，ASA Ⅰ~Ⅱ级，将80例产妇随机分为A、B、C 3组，其中A、B组各27例，C组26例。麻醉药，A组0.5%盐酸罗哌卡因10 mg+舒芬太尼5 μg；B组0.5%盐酸罗哌卡因11.25 mg+舒芬太尼5 μg；C组0.5%盐酸罗哌卡因12.5 mg+舒芬太尼5 μg。结果3组产妇麻醉阻滞起效时间、阻滞平面达T₈及以上的比例及阻滞平面达T₈以上时间差异均无统计学意义（P>0.05）。3组麻醉效果分级比较差异有统计学意义（P < 0.01）。术中使用升压药的比例，C组高于A组和B组（P < 0.05）。3组新生儿Apgar评分与时间因素、组间因素、时间因素和组间的交互效应的关系均无统计学意义（P>0.05）。结论剖宫产手术中罗哌卡因联合舒芬太尼等比重蛛网膜下腔阻滞时，盐酸罗哌卡因的适宜剂量为11.25 mg，可以满足剖宫术麻醉起效快、效果好的需求。

Analysis of the effects of different doses of ropivacaine mixed with sufentanil in cesarean section with equal specific gravity spinal anesthesia

ObjectiveTo investigate the anesthetic effects of different doses of ropivacaine combined with sufentanil in cesarean section with equal specific gravity spinal anesthesia.MethodsEighty parturients with full-term cesarean section(ASA Ⅰ-Ⅱ) were randomly divided into the group A(n=27), group B(n=27) and group C(n=26).The group A, group B and group C were anesthetized with 10 mg of 0.5% ropivacaine hydrochloride combined with 5 μg of sufentanil, 11.25 mg of 0.5% ropivacaine hydrochloride combined with 5 μg of sufentanil and 12.5 mg of 0.5% ropivacaine hydrochloride combined with 5 μg of sufentanil, respectively.ResultsThe differences of the effective time of anesthesia block, and proportion and time of block level above T₈ among three groups were not statistically significant(P>0.05), and the differences of the classification of anesthetic effects among three groups were statistically significant(P < 0.01).The proportion of intraoperative use of hyperensort in group C was higher than that in group A and group B(P < 0.05).The differences of the interaction effects of neonatal Apgar scores with time factor and group factor, and interaction effects of time factor with group factor among three groups were not statistically significant(P>0.05).ConclusionsWhen ropivacaine combined with sufentanil in equal specific gravity spinal anesthesia during cesarean section, the appropriate dose of ropivacaine hydrochloride for 11.25 mg can meet the needs of rapid onset and good effects of anesthesia.