周围型肺癌CT征象与Ki-67、p53表达的关系

目的 探讨周围型肺癌（PLC）CT征象与Ki-67、p53表达的关系。方法 选取2016年1月～2022年2月在本院就诊的108例PLC患者为研究对象，采用飞利浦256层螺旋CT检查患者的CT征象，并检测PLC组织中Ki-67、p53的表达水平，分析PLC患者的病理组织类型、分化程度以及CT征象与Ki-67和p53表达的关系。结果 PLC组织中，Ki-67和p53阳性表达率分别为69.44%(75/108)、51.85%(56/108);CT主要表现为瘤体直径≥3.0 cm、分叶征、棘状突起征、毛刺征、磨玻璃征、增强值≥20 Hu和肺门、纵隔淋巴结肿大，而胸膜凹陷征、空气支气管征、空洞征、空泡征、钙化征相对较少；腺癌的Ki-67阳性表达率低于鳞癌（P<0.05），腺癌和鳞癌的p53阳性表达率差异无统计学意义（P>0.05）;PLC的分化程度越低，Ki-67和p53阳性表达率越高（P<0.05）；瘤体直径≥3.0 cm、有分叶征、棘状突起征、毛刺征、增强值≥20 Hu和肺门、纵隔淋巴结肿大的PLC,Ki-67阳性表达率较高，且有磨玻璃征和空泡征的PLC,Ki-67阳性表...

Relationship between CT signs and Ki-67, p53 in peripheral lung cancer

  Objective  To explore the relationship between CT signs and Ki-67, p53 in peripheral lung cancer (PLC).  Methods  A total of 108 patients with PLC treated in the hospital were enrolled between January 2016 and February 2022. CT signs were examined by Philips 256-slice spiral CT. The expression levels of Ki-67 and p53 in PLC tissues were detected. The relationship between pathological tissue types, differentiation degree, CT signs and Ki-67, p53 was analyzed.  Results  In PLC tissues, positive expression rates of Ki- 67 and p53 were 69.44% (75/108) and 51.85% (56/108), respectively. The main CT findings included pleural indentation, tumor diameter ≥3.0 cm, lobulation sign, spiculate protuberance sign, spicule sign, enhancement value ≥20 Hu, hilar and mediastinal lymph node enlargement, while CT findings (air bronchus sign, cavity sign, glass sign, vacuole sign, calcification sign) were relatively rare. The positive expression rate of Ki-67 in adenocarcinoma was lower than that in squamous cell carcinoma (P < 0.05), but there was no significant difference in the positive expression rate of p53 between adenocarcinoma and squamous cell carcinoma (P > 0.05). The lower the differentiation degree of PLC, the higher the positive expression rates of Ki-67 and p53 (P < 0.05). The positive expression rate of Ki-67 was higher in patients with tumor diameter ≥ 3.0 cm, lobulation sign, spiculate protuberance sign, spicule sign, enhancement value ≥20 Hu, hilar and mediastinal lymph node enlargement, while which was lower in patients with glass sign and vacuole sign (P < 0.05). The positive expression rate of p53 was higher in patients with tumor diameter ≥3.0 cm, lobulation sign, spiculate protuberance sign, spicule sign, enhancement value ≥20 Hu, hilar and mediastinal lymph node enlargement (P < 0.05).  Conclusion  The expressions of Ki-67 and p53 are closely related to CT signs in PLC patients.