| 高尿酸血症与慢性肾脏病相关性研究进展 |
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| 作者姓名： | 林思梅 周虹 杨宝学 |
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| 作者单位： | 北京大学基础医学院药理学系，北京，100191，中国 |
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| 基金项目： | 国家自然科学基金（No. 81620108029，No. 81974083，No. 81873597） |
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| 摘 要： | 高尿酸血症（hyperuricemia，HUA）在中国的患病率超过13%（男性高达18.5%），并且呈现逐年升高的趋势。高尿酸血症可影响肾脏，直接导致急慢性尿酸性肾病或尿酸结石，并表现为以尿酸引起的慢性间质性肾炎、肾纤维化等为特征的慢性肾脏病（chronic kidney disease，CKD）。CKD 是慢性病程的肾脏结构和功能发生障碍的进展性疾病，严重影响人类健康和生活质量。该文综述了高尿酸血症对肾脏的影响和尿酸与CKD 的相关性、致病机制及治疗策略的最新进展。
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| 关 键 词： | 尿酸 慢性肾脏病 炎症 氧化应激 降尿酸治疗 |
The Relationship between Hyperuricemia and Chronic KidneyDisease |
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| Authors: | LIN Si-mei ZHOU Hong YANG Bao-xue |
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| Institution: | Department of Pharmacology，School of Basic Medical Sciences，Peking University，Beijing，100191，China |
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| Abstract: | In China，the prevalence of hyperuricemia （HUA） is over 13% （males as high as 18.5%），and shows the trend of increasing year by year. Hyperuricemia mainly affects the kidney，leading directly to acute/chronic uric acid nephropathy or uric acid stone，and manifests chronic kidney disease （CKD） characterized by chronic interstitial nephritis and renal fibrosis caused by uric acid. CKD is a progressive disease in which the structure and function of kidney are impaired，which has seriously affected human health and living quality. This article reviews the effect of hyperuricemia on the kidney，the correlation between uric acid and CKD，the pathogenesis and the therapeutic strategy. |
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| Keywords: | uric acid chronic kidney disease inflammation oxidative stress uric acidlowering therapies
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