| 原发性膜性肾病(PMN)的诊治进展 |
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| 引用本文： | 谢琼虹.原发性膜性肾病(PMN)的诊治进展[J].复旦学报(医学版),2020,47(4):615-621. |
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| 作者姓名： | 谢琼虹 |
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| 作者单位： | 复旦大学附属华山医院肾病科 上海 200040 |
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| 基金项目： | 国家自然科学基金（81670697） |
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| 摘 要： | 原发性膜性肾病（primary membranous nephropathy，PMN）是成人原发性肾病综合征的主要原因，近年来在国内发病率逐年增加。随着抗磷脂酶A2受体（PLA2R）抗体和抗I型血小板域蛋白7A（THSD7A）抗体的发现，我们对PMN发病机制的认识也取得重要的进展。本文将从膜性肾病的认识历程、PLA2R的临床应用价值、免疫抑制治疗的时机、免疫抑制治疗方案方面对PMN的诊治进展进行综述。
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| 关 键 词： | 原发性膜性肾病(PMN) PLA2R 治疗 |
| 收稿时间： | 2019-09-23 |
Treatment progress on primary membranous nephropathy(PMN) |
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| XIE Qiong-hong,CHEN Rui-ying,XUE Jun,HAO Chuan-ming.Treatment progress on primary membranous nephropathy(PMN)[J].Fudan University Journal of Medical Sciences,2020,47(4):615-621. |
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| Authors: | XIE Qiong-hong CHEN Rui-ying XUE Jun HAO Chuan-ming |
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| Institution: | Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China |
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| Abstract: | Primary membranous nephropathy(PMN)is the most common cause of primary nephrotic syndrome in adults.The prevalence of PMN in China was significantly increased during the past decade.The identification of autoantibodies against phospholipidase A2 receptor(PLA2R)and thrombospondin type-1 domain-containing 7A (THSD7A) is helpful in the understanding and treatment of PMN. This review focuses on the clinical significance of PLA2R,the time and regimens of immunosuppressive therapy in PMN. |
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| Keywords: | primary membranous nephropathy(PMN) PLA2R treatment |
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