腹腔镜卵巢打孔术联合未成熟卵泡穿刺术治疗难治性多囊卵巢综合征效果评价

目的 探讨腹腔镜卵巢打孔术联合经阴道未成熟卵泡穿刺术(IMFA)对难治性多囊卵巢综合征患者生育储备功能的影响。方法 选取2018年3月—2019年6月本院收治的难治性多囊卵巢综合征患者96例,采取随机数字表法将其分为对照组和实验组,各48例。对照组患者给予腹腔镜卵巢打孔术进行治疗,实验组患者在对照组基础上联合使用IMFA进行治疗。对比两组术后疗效指标(自然排卵率、妊娠率、流产率)、生育储备功能血清黄体生成素(LH)、睾酮(T)、雌二醇(E2)、促卵泡生成素(FSH)]情况。结果 治疗后,实验组自然排卵率(87.50%)、妊娠率(70.83%),均高于对照组(64.58%)、(45.83%),且实验组流产率(10.42%)低于对照组(27.08%),差异具有统计学意义(P<0.05);治疗后,实验组LH(9.15±0.64)mU/mL、T(0.97±0.18)pg/mL、LH/FSH(1.51±0.24)水平均低于对照组(13.50±2.33)mU/mL、(1.52±0.28)pg/mL、(5.10±0.69),且实验组FSH(6.22±0.94)mU/mL水平高于对照组(5.10±0.69)mU/mL,(P<0.05)。结论 腹腔镜卵巢打孔术联合IMFA可提高难治性多囊卵巢综合征患者的自然排卵率、妊娠率,降低流产率,改善患者的生育储备功能。

Efficacy of laparoscopic ovarian drilling combined with transvaginal immature follicular puncture in treatment of patients with refractory polycystic ovary syndrome

Objective To investigate the effect of laparoscopic ovarian drilling combined with transvaginal immature follicular puncture (IMFA)) on the fertility reserve function of the patients with refractory polycystic ovarian syndrome (PCOS). Methods From March 2018 to June 2019, 96 patients with refractory PCOS were randomly divided into a control group (n=48) and a trial group (n=48). The patients in the control group were treated with the laparoscopic ovarian drilling, and the patients in the trial group were treated with transvaginal IMFA on the basis of the control group. The postoperative curative effect indexes (natural ovulatory rate, pregnancy rate, and abortion rate) and fertility reserve function were investigated and compared between two groups. Results After the treatment, the natural ovulatory rate and pregnancy rate in the trial group were 87.50% and 70.83% respectively, which were higher than those in the control group (64.58% and 45.83% respectively); the abortion rate in the trial group was 10.42%, which was lower than that in the control group (27.08%), and the differences were statistically significant (P<0.05). After the treatment, in the trial group, the levels of LH, T and LH/FSH were (9.15±0.64) mU/ml, (0.97±0.18) pg/ml, and (1.51±0.24) respectively, which were lower than those in the control group , but the level of FSH in trial group was (6.22±0.94) mU/ml, which was significantly higher than that of the control group . Conclusion The laparoscopic ovarian drilling combined with transvaginal IMFA can improve the natural ovulatory rate in patients with refractory polycystic ovarian syndrome.