| 利拉鲁肽致不良反应文献分析 |
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| 引用本文： | 董士超,刘鸿杉,王靖宇,蔡磊,王荣环. 利拉鲁肽致不良反应文献分析[J]. 中国医院药学杂志, 2020, 40(3): 310-314,348. DOI: 10.13286/j.1001-5213.2020.03.14 |
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| 作者姓名： | 董士超 刘鸿杉 王靖宇 蔡磊 王荣环 |
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| 作者单位： | 1. 天津医科大学第二医院药学部, 天津 300211;2. 天津市卫生计生综合监督所, 天津 300070;3. 天津医科大学朱宪彝纪念医院, 天津 300070;4. 天津市第三中心医院药学部, 天津 300170 |
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| 基金项目： | 国家自然科学基金（编号：81603461） |
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| 摘 要： | 目的： 探讨利拉鲁肽致不良反应的发生规律和特点，为临床合理用药提供依据。方法： 检索自2010年至2019年中CNKI、万方、VIP、PubMed，Web of Science等数据库的国内外文献，进行整理分析。结果： 总共收集16例不良反应，男性10例，女性6例，以50岁以上患者发生率较高（11例，68.75%）。不良反应多发生于6个月内，累及多个组织/器官，以消化系统损害（31.25%）、皮肤及附件系统损害（18.75%）以及肝胆系统损害（18.75%）为主。结论： 临床中使用利拉鲁肽要加强用药监护，密切防范ADR的发生，尤其对于老年患者、肝肾功能不全及既往存在药物过敏史的患者。
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| 关 键 词： | 利拉鲁肽 不良反应 文献分析 |
| 收稿时间： | 2019-06-12 |
Literature analysis of adverse drug reactions induced by liraglutide |
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| DONG Shi-chao,LIU Hong-shan,WANG Jing-yu,CAI Lei,WANG Rong-huan. Literature analysis of adverse drug reactions induced by liraglutide[J]. Chinese Journal of Hospital Pharmacy, 2020, 40(3): 310-314,348. DOI: 10.13286/j.1001-5213.2020.03.14 |
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| Authors: | DONG Shi-chao LIU Hong-shan WANG Jing-yu CAI Lei WANG Rong-huan |
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| Affiliation: | 1. Department of Pharmacy, Second Hospital Affiliated to Tianjin Medical University, Tianjin 300211, China;2. Tianjin Municipal Inspection Bureau for Health and Family Planning, Tianjin 300070, China;3. Tianjin Medical University Metabolic Diseases Hospital, Tianjin 300070, China;4. Department of Pharmacy, Tianjin Third Central Hospital, Tianjin 300170, China |
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| Abstract: | OBJECTIVE To explore the general regularity and characteristics of adverse reactions induced by liraglutide, and to provide reference for rational drug use in clinic. METHODS The domestic and foreign literatures of CNKI, Wanfang, VIP, PubMed and Web of Science from 2010 to 2019 were searched and analyzed. RESULTS A total of 16 adverse reactions were collected, including 10 males and 6 females. The incidence of adverse reactions was higher in patients over 50 years old(11 cases, 68.75%). Adverse reactions mostly occurred within 6 months, involving multiple tissues/organs, mainly digestive system disorders(31.25%), skin and appendages disorders(18.75%) and hepatobiliary system disorders(18.75%). CONCLUSION Clinicians should pay more attention to the safety monitoring of liraglutide, especially in elder patients, patients with liver and kidney insufficiency and allergic history. |
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| Keywords: | liraglutide adverse reactions literature analysis |
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