幽门螺杆菌感染对功能性消化不良患者的自主神经功能和降钙素基因相关肽的影响

目的探讨幽门螺杆菌(H.pylori)感染对功能性消化不良(FD)患者自主神经功能和降钙素基因相关肽的影响。方法以符合罗马Ⅳ诊断标准的31例FD患者为研究对象,根据是否感染H.pylori将FD患者分为H.pylori+组和H.pylori-组,分别对两组患者进行消化不良症状指数(SID)、尼平消化不良指数(NDI)和医院焦虑抑郁量表的测评,并检测患者的心率变异性(HRV)及降钙素基因相关肽(CGRP)的表达。结果两组患者在SID(Z=-0.858,P=0.858)、NDI(Z=-1.464,P=0.143)和医院抑郁评分(Z=0.699,P=0.485)方面差异无统计学意义,但H.pylori+组患者的医院焦虑评分明显高于H.pylori-组(Z=-2.470,P=0.014)。H.pylori+组的CGRP水平为(0.999±0.274)ng/ml,明显高于H.pylori-组的(0.812±0.172)ng/ml(t=2.238,P=0.033)。两组患者的HRV在极低频率(t=-1.210,P=0.236)、低频功率(LF)(t=0.419,P=0.678)、高频功率(HF)(...

Effect of Helicobacter pylori Infection on Autonomic Nervous Function and Calcitonin Gene-related Peptide in Patients with Functional Dyspepsia

Objective To investigate the effects of Helicobacter pylori(H.pylori)infection on autonomic nervous function and calcitonin gene-related peptide in patients with functional dyspepsia(FD). Methods Thirty-one patients with FD matching Rome Ⅳ criteria were included and divided into H.pylori-positive group and H.pylori-negative group.All patients were evaluated by Symptom Index of Dyspepsia(SID),Nepean Dyspepsia Index(NDI),and Hospital Anxiety and Depression Scale(HADS).Their heart rate variability(HRV)and calcitonin gene-related peptide(CGRP)level were also measured. Results There were no significant differences in SID(Z=-0.858, P=0.858),NDI(Z=-1.464, P=0.143),and Hospital Depression Scale score(Z=0.699, P=0.485).However,the Hospital Anxiety Scale score was significantly higher in H.pylori-positive group than the H.pylori-negative group(Z=-2.470, P=0.014).The level of CGRP in H.pylori-positive group[(0.999±0.274)ng/ml]was significantly higher than that in the H.pylori-negative group[(0.812±0.172)ng/ml;t=2.238, P=0.033].HRV data showed no significant difference between these two groups at very low frequency(t=-1.210, P=0.236),low frequency(LF)(t=0.419, P=0.678),high frequency(HF)(t=0.612, P=0.546),LF/HF(t=-0.882, P=0.399),and total power(t=-0.963, P=0.344). Conclusion In FD patients,patients with H.pylori-positive FD patients have higher depression and CGRP levels than those without H.pylori infection,although their dyspepsia symptoms and HRV show no notable changes.