无抽搐电休克对精神分裂症氧化应激和认知功能的影响

目的 探究精神分裂症患者无抽搐电休克治疗(MECT)后认知功能、氧化水平的变化情况。方法 选取2019年3月—2020年7月本院收治的64例精神分裂症患者为研究对象,观察患者MECT治疗疗效、治疗前后认知功能及氧化水平变化。结果 64例患者中,37例(57.8%)患者治愈,19例(29.7%)患者显效,7例(10.9%)有效,1例(1.6%)无效,治疗总有效率为98.4%。治疗前、治疗后患者WCST应答总数差异无统计学意义(t=0.328,P=0.744),治疗后WCST正确应答数多于治疗前,WCST错误应答数少于治疗前,WCST完成时间短于治疗前,差异有统计学意义(t=4.977、4.742、2.387,P<0.001,P<0.001,P=0.018);治疗后一氧化氮水平(NO)水平低于治疗前、谷胱甘肽过氧化物酶(GPX)水平、超氧化物歧化酶(SOD)水平高于治疗前,差异有统计学意义(t=6.684、3.887、2.066,P<0.001,P<0.001,P=0.041)。结论 MECT对精神分裂症患者认知功能有明显改善作用,降低体内氧自由基,平衡氧化水平,疗效较好,可临床推广应用。

Changes of cognitive function and oxidation level in patients with schizophrenia after electroconvulsive therapy without convulsions

Objective To explore the changes of cognitive function and oxidation level in patients with schizophrenia after non-convulsive electroconvulsive therapy (MECT). Methods Sixty-four patients with schizophrenia admitted to our hospital were selected as research subjects from March 2019-July 2020.To observe the patient‘s MECT treatment efficacy, cognitive function and oxidation level changes before and after treatment. Results Of the 64 patients, 37 (57.8%) were cured, 19 (29.7%) were markedly effective, 7 (10.9%) were effective, and 1 (1.6%) was ineffective. The total effective rate was 98.4%; there was no difference in the total number of WCST responses between patients before and after treatment Statistically significant (t=0.328, P=0.744). After treatment, the number of correct WCST responses was more than before treatment, the number of WCST error responses was less than before treatment, and the completion time of WCST was shorter than before treatment. The difference was statistically significant (t=4.977、4.742、2.387, P<0.001, P<0.001, P=0.018); after treatment Nitric oxide levels (NO) levels were lower than before treatment, glutathione peroxidase (GPX) levels, and superoxide dismutase (SOD) levels were higher than before treatment, the differences were statistically significant (t=6.684、3.887、2.066, P<0.001, P<0.001, P=0.041). Conclusion MECT can significantly improve the cognitive function of patients with schizophrenia, reduce oxygen free radicals in the body, and balance the level of oxidation. It has a good effect and can be used in clinical applications.