急性缺血性脑卒中患者溶栓治疗后半暗带CT灌注成像参数的预测价值

目的  研究急性缺血性脑卒中（AIS）患者溶栓治疗后CT灌注成像参数变化及其对预后的早期预测价值。方法  选取2019年3月~2022年3月我院90例AIS患者临床资料为样本开展回顾性研究，均于随访3月时采用改良Rankin量表（mRS）评分并根据结果分组，以mRS≤2分为预后良好组（n=31），>2分为预后不良组（n=59），比较两组溶栓治疗后半暗带CT灌注成像参数脑血容量（CBV）、脑血流量（CBF）、平均通过时间（MTT）和达峰时间（TTP），并以健侧为对照计算各参数相对值rCBF、rCBV、rMTT和rTTP，分析各参数对AIS患者预后的预测价值。结果  溶栓治疗后预后不良组AIS患者半暗带CBF、CBV、rCBF和rCBV均低于预后良好组（P < 0.05），MTT和TTP均高于预后良好组（P < 0.05），两组rMTT和rTTP比较未见差异, 无统计学意义（P>0.05）；CBF、CBV、MTT和TTP预测AIS患者预后的曲线下面积（AUC）分别为0.701、0.662和0.698，4项参数联合预测的AUC为0.817，敏感度为93.55%，特异性为64.41%；rCBF和rCBV预测AIS患者预后的AUC分别为0.724和0.798，两项参数联合预测的AUC为0.812，敏感度为96.77%，特异性为57.63%。结论  CT灌注成像可对AIS患者半暗带血流灌注水平进行定量分析，检测溶栓治疗后CBF、CBV、MTT和TTP等参数及其与健侧镜像区脑组织相对值可为早期评估患者预后提供参考。

Early predictive value of penumbra CT perfusion imaging parameters on prognosis of patients with acute ischemic stroke after thrombolytic therapy

  Objective  To explore the changes in CT perfusion imaging parameters in patients with acute ischemic stroke (AIS) after thrombolytic therapy and their early predictive value on prognosis.  Methods  The clinical data of 90 patients with AIS in the hospital were enrolled from March 2019 to March 2022 for retrospective analysis. All patients were followed up for 3 months with modified Rankin scale (mRS) score and grouped according to the results. Patients with MRS≤2 points were assigned to good prognosis group (n=31), and patients with score >2 points were classified into poor prognosis group (n=59). The penumbra CT perfusion imaging parameters including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) were compared between the two groups after thrombolytic therapy. The healthy side was used as the control to calculate the relative values of rCBF, rCBV, rMTT and rTTP, and the predictive value of each parameter on the prognosis of AIS patients was analyzed.  Results  After thrombolytic therapy, the CBF, CBV, rCBF and rCBV in penumbra in poor prognosis group were significantly lower than those in good prognosis group (P < 0.05).The MTT and TTP were significantly longer than those in good prognosis group (P < 0.05), but there were no statistical differences in rMTT and rTTP between the two groups (P>0.05). The AUCs of CBF, CBV, MTT and TTP in predicting the prognosis of AIS patients were 0.701, 0.662 and 0.698 respectively. The AUC, sensitivity and specificity of the combined prediction of the four parameters were 0.817, 93.55% and 64.41%. The AUCs of rCBF and rCBV in predicting the prognosis of AIS patients were 0.724 and 0.798 respectively. The AUC, sensitivity and specificity of the combined prediction of the two parameters were 0.812, 96.77% and 57.63%.  Conclusion  CT perfusion imaging can quantitatively analyze the blood perfusion level in the penumbra of AIS patients, and the detection of CBF, CBV, MTT and TTP parameters after thrombolytic therapy and their relative values in brain tissue in the mirror region of the healthy side can provide a reference for early assessment of prognosis of patients.