右美托咪定与丙泊酚对外科术后机械通气患者镇静效果及血流动力学的影响

目的 探究右美托咪定与丙泊酚对外科术后机械通气患者镇静效果及血流动力学的影响。方法 将我院60例外科手术后机械通气患者作为研究对象,电脑随机将其分成右美托咪定组和丙泊酚组,各30例。右美托咪定组给予右美托咪定治疗,丙泊酚组给予丙泊酚治疗,比较两种方法的镇静效果及对血流动力学的影响。结果 镇静30 min后,两组的Ramsay镇静评分对比差异无统计学意义(Z=1.23,P>0.05);右美托咪定组心动过缓(6.67%)、低血压(13.33%)、低血压合并心动过缓(3.33%)发生率分别低于丙泊酚组(30.00%、36.67%、26.67%),两组间对比差异有统计学意义(χ2分别为5.45、4.36、6.41,P均<0.05)。结论 给予外科术后机械通气患者右美托咪定或丙泊酚,均有更好的镇静效果,但右美托咪定对于血流动力学的影响较小,更适用于机械通气患者。

Effects of dexmedetomidine and propofol on sedation and hemodynamics of patients undergoing mechanical ventilation after surgery

Objective To explore the effect of dexmedetomidine and propofol on sedation and hemodynamics of patients with postoperative mechanical ventilation. Methods A total of 60 patients with mechanical ventilation after surgery in a hospital were randomly divided into a dexmedetomidine group and a propofol group, with 30 patients in each group. The dexmedetomidine group was treated with dexmedetomidine, and the propofol group was treated with propofol. The sedative effect and hemodynamics of the two groups were compared. Results After 30 minutes of sedation, there was no statistically significant difference in Ramsay sedation scores between the two groups (Z=1.23, P>0.05). The incidence rates of bradycardia (6.67%), hypotension (13.33%), and hypotension combined with bradycardia (3.33%) in the dexmedetomidine group were lower than those in the propofol group (30.00%, 36.67%, and 26.67% respectively), and the differences between the two groups were statistically significant (χ2=5.45, 4.36, 6.41, all P<0.05). Conclusion Dexmedetomidine or propofol has a better sedative effect in postoperative patients with mechanical ventilation, but dexmedetomidine has less effect on hemodynamics and is more suitable for patients with mechanical ventilation.