尼可刹米结合无创正压通气对慢性阻塞性肺疾病急性加重期伴呼吸衰竭患者动脉血气指标的影响

目的 探讨针对慢性阻塞性肺疾病(COPD)急性加重期伴呼吸衰竭患者采取尼可刹米结合无创正压通气治疗对其动脉血气指标的影响。方法 采用随机数表法将本院2017年10月—2019年10月收治的83例COPD急性加重期伴呼吸衰竭患者分为对照组42例、观察组41例。对照组予以尼可刹米治疗,观察组在对照组基础上结合无创正压通气联合治疗。对比分析2组临床疗效、1秒用力呼气量(FEV1)、用力肺活量(FVC)、1秒用力呼气量/用力肺活量比值(FEV1/FVC)、动脉氧分压(PaO2)、动脉二氧化碳分压(PaCO2)及动脉血氧饱和度(SaO2)。结果 观察组治疗总有效率92.68%,较对照组(69.05%)高(χ2=7.448,P=0.006);观察组治疗后FVC(2.16±0.27)L、FEV1(2.94±0.36)L、FEV1/FVC(55.39±4.22)%,均高于对照组的(1.64±0.29)L、(2.27±0.43)L、(49.71±4.39)%,差异均有统计学意义(P＜0.01);观察组治疗后PaO2(90.73±7.11)mmHg、SaO2(93.13±5.75)%,均高于对照组的(86.42±7.20)mmHg、(87.10±6.12)%,且PaCO2(41.14±5.17)mmHg,低于对照组的(48.89±5.22)mmHg,差异均有统计学意义(P＜0.01)。结论 针对COPD急性加重期伴呼吸衰竭患者采取尼可刹米结合无创正压通气治疗,能够有效改善患者肺功能,调节动脉血气指标,值得推广。

Effect of nikethamide combined with noninvasive positive pressure ventilation on arterial blood gas indexes in patients with acute exacerbation of chronic obstructive pulmonary disease with respiratory failure

Objective To investigate the effect of nikethamide combined with noninvasive positive pressure ventilation on arterial blood gas indexes in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods A total of 83 patients with acute exacerbation of COPD with respiratory failure admitted to a hospital from October 2017 to October 2019 were randomly divided into a control group (42 cases) and an observation group (41 cases). The control group was treated with nikethamide, and the observation group was treated with the noninvasive positive pressure ventilation on the basis of the control group. The clinical efficacy, forced expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC, arterial oxygen partial pressure (PaO2), arterial carbon dioxide partial pressure (PaCO2) and arterial oxygen saturation (SaO2) were investigated, analyzed and compared. Results The total effective rate of was 92.68% in the observation group, which was higher than that in the control group (69.05%), and the difference was statistically significant (χ2=7.448, P=0.006). After the treatment, FVC , FEV1 and FEV1/FVC in the observation group were higher than those in the control group , with statistically significant differences (P < 0.01). After the treatment, the indexes of PaO2 and SaO2 in the observation group were higher than those in the control group , and PaCO2 was lower than that in the control group , with a statistically significant difference (P < 0.01). Conclusion The treatment of nikethamide combined with noninvasive positive pressure ventilation in patients with acute exacerbation of COPD with respiratory failure can effectively improve the pulmonary function and regulate arterial blood gas indexes, which is worthy of promotion.