| 环磷酰胺对大鼠骨组织形态计量学的影响 |
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| 引用本文： | 王永东,吴铁,刘晓青,崔燎,李青南. 环磷酰胺对大鼠骨组织形态计量学的影响[J]. 中国药理学通报, 2001, 17(5): 575-578 |
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| 作者姓名： | 王永东 吴铁 刘晓青 崔燎 李青南 |
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| 作者单位： | 广东医学院药理学教研室、 |
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| 摘 要： | 目的 观察不同剂量的环磷酰胺对大鼠骨组织形态计量学的影响 ,并探讨用环磷酰胺建立大鼠骨质疏松动物模型。方法 用三种不同剂量的环磷酰胺分别按每天 1 5mg·kg-1,4 5mg·kg-1,12 5mg·kg-1,连续灌胃大鼠 15d ,同时设生理盐水对照组。 15d后处死大鼠 ,取右侧股骨远端不脱钙包埋切片作骨组织形态计量学测量。结果 4 5mg·kg-1,12 5mg·kg-1剂量的环磷酰胺可造成大鼠股骨骨量显著丢失 ,1 5mg·kg-1剂量的环磷酰胺对大鼠骨量没有影响。结论 环磷酰胺能改变大鼠骨组织形态及结构 ,可建立骨质疏松动物模型。
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| 关 键 词： | 环磷酰胺 骨质疏松 骨组织形态计量学 大鼠 |
| 文章编号： | 1001-1978(2001)05-0575-04 |
| 修稿时间： | 2000-04-18 |
The effects of cyclophosphamide on bone histomorphometry in rats |
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| WANG Yong Dong,WU Tie,LIU Xiao Qing,CUI Liao,LI Qing Nan. The effects of cyclophosphamide on bone histomorphometry in rats[J]. Chinese Pharmacological Bulletin, 2001, 17(5): 575-578 |
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| Authors: | WANG Yong Dong WU Tie LIU Xiao Qing CUI Liao LI Qing Nan |
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| Affiliation: | WANG Yong Dong,WU Tie,LIU Xiao Qing,CUI Liao,LI Qing Nan 1 |
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| Abstract: | AIM To study the effects of doses of cyclophosphamide(CP) on bone histomorphometry in rats,and evaluted the rat model of osteoporosis after cyclophosphamide administration. METHOD CP at doses of 1 5, 4 5 and 13 5 mg·kg -1 were given to the rats orally everyday for 15 days respectively.in addition, soldium chloride used as control group. At the end of 15 days, the right distal femur were processed to undecalcified sections at 4um and 8 μm for histomorphometric analysis. RESULT Trabecullar bone mass at doses of 4 5 and 13 5 mg·kg -1 CP reduced markedly, While dose of 1 5 mg·kg -1 CP has no influence on trabecullar bone mass.CONCLUSION Cyclophosphamide has stronger influences on bone tissue and structure in rats. It can be used to make the rat model of osteoporosis. |
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| Keywords: | cyclophosphamide osteoporosis bone histomorphometry rat |
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