DNA-ploidy and survival in gastric carcinomas: a flow-cytometric study |
| |
Authors: | G Baretton O Carstensen M Schardey U Löhrs |
| |
Institution: | (1) Institut für Pathologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, W-2400 Lübeck 1, Federal Republic of Germany;(2) Department of Surgery, Medical University of Lübeck, Lübeck, Federal Republic of Germany |
| |
Abstract: | Summary In 125 gastric carcinomas the nuclear DNA content was determined by flow cytometry from formalin-fixed and paraffin-embedded tissue of surgical specimens. The carcinomas were of intestinal or mixed type (85), and diffuse type (40). DNA-aneuploidy was found in 46% of the intestinal type and in 42% of the mixed type, but only in 15% of the diffuse-type carcinomas (P<0.01). The total rate of DNA-aneuploidy was 34%. Carcinomas localized in the cardia were more frequently DNA-aneuploid than tumours in other localizations (P<0.01). DNA-aneuploid carcinomas had metastasized more frequently to regional lymph nodes (P<0.05) whereas no correlations with tumour stage and cytological/histological grade were detected. In 94 patients follow-up data were available. DNA-aneuploidy was associated with a statistically significant poorer prognosis when compared to DNA-diploid tumours only in advanced gastric carcinomas with lymph node metastases (P=0.0488) and in the subgroup of advanced intestinal and mixed-type tumours (P=0.0289). |
| |
Keywords: | Flow cytometry Gastric cancer DNA-aneuploidy Prognosis Histological type |
本文献已被 SpringerLink 等数据库收录! |