泌尿生殖道支原体的检测和药敏分析

目的：了解沈阳地区2000-2002年泌尿生殖道分泌物中分离的解脲脲原体(Uu)和人型支原体(Mh)的药物敏感情况。方法：应用Mycoplasma IST试剂盒对Uu和Mh进行检测，并对6种抗菌药物的药敏试验进行分析。结果：6966例可疑泌尿生殖道感染患者中，2365例检出支原体，其中Uu 1589例，Mh 154例，Uu Mh 622例。3组检出的支原体对抗菌药物敏感性由高到低依次为Uu、Mu、Uu Mh。3组检出的支原体对多西环素、交沙霉素、原始霉素敏感性均很高，对氧氟沙星的敏感性较低。支原体对6种抗菌药物的敏感性逐年下降，出现对6种抗菌药物均耐药的支原体。结论：支原体对抗菌药物的耐药性逐年增加。支原体药敏试验可以指导合理用药，减少耐药株的产生。

Detection of urogenital mycoplasma and analysis of their susceptibility testing

Objective: To explore the susceptibility of ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh) to antimicrobials in urogenital tract in Shenyang area from 2000 to 2002. Methods: The samples from 6 966 patients suspected as urogenital infection were investigated by using Mycoplasma IST kits. The susceptibility tests for 6 kinds of antimicrobials were also performed. Results: Mycoplasmas were detected in 2365 patients (33.95%). Among these 2 365 patients, the infection rate of Uu, Mh or Uu-Mh mix were 67.19% (1589 cases), 6.51% (154 cases) or 26.30% (622 cases) respectively.The susceptibili of Uu, Mh and Uu+Mh decreased from high to low by one. All isolated mycoplasmas were supsceptible to doxycycline, josamycin and pristinamycine, but lower suseceptible to ofloxacin. The susceptibility to all 6 kinds of antimicrobials was decreased yearly. Conclusions: The drug resistances are increased in mycoplasma. The tests for susceptibility can be important for selecting effective drugs in the clinic treatment of mycoplasma infections.