基质金属蛋白酶7 在大肠正常黏膜、腺瘤及癌组织中的表达

 目的 探讨基质金属蛋白酶（MMP-7）的表达与大肠癌发生及大肠癌病理指标间的关系. 方法 采用免疫组化技术检测15例正常大肠黏膜（NM）、27例大肠腺瘤（Ad）、81例大肠癌（CC）中MMP-7的表达. 结果 从NM到Ad 到CC,MMP-7、TIMP-1的表达逐渐增高、增强,MMP-7在组间存在显著差别（P〈0.01）. MMP-7表达与大肠癌的淋巴结转移、远处转移、Duke＇s分期呈正相关,黏液癌中表达明显高于高分化腺癌,年龄低于60岁的大肠癌患者MMP-7表达显著强于60及60岁以上者. 结论 MMP-7参与了大肠癌发生、发展的全过程,并具有高度的特异性,可作为大肠癌的预测及预后评估因子.阻断MMP-7的表达和活性有可能成为抗肿瘤转移治疗的一个新途径.

The Expression of MMP-7 in NM、Ad and CC

Objective 　To explore the relationship between MMP-7 expression and occurrence , biological behaviors of CC. Methods 　SP immunohistochemical staining was used to examine expression of MMP-7 among 15 cases of NM , 27 cases of Ad and 81 cases of CC paraffin-embedded specimens. Rank sum test was used to analyze the expression of MMP-7. Results 　The expression of MMP-7 from NM to Ad to CC appeared an upward tendency . The significant differences of MMP-7 expression were present any two groups ( P < 0. 01 , P < 0. 01 , P < 0. 01) . The expression of MMP-7 was positively correlated with lymph node metastasis ( P < 0. 05) , distant metastasis ( P < 0. 01) , Duke’s stage . Expression in mucous group was higher than that in high differentiation group ( P < 0. 01) . The MMP-7 expression in patients aged below 60y was stronger than that in over 60y and 60y ( P < 0. 05) . Conclusion 　MMP-7 was involved in the occurrence and development of CC with high specialty , so it could be a predictive and prognostic factor of CC. Decreasing the activity of MMP-7 might be a new pathway for CC treatment .