| 食管鳞癌组织中半乳糖凝集素-3和Bcl-2蛋白的表达 |
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| 引用本文： | 庞霞,郑湘予,李晟磊,赵志华,陈奎生.食管鳞癌组织中半乳糖凝集素-3和Bcl-2蛋白的表达[J].郑州大学学报(医学版),2010,45(1). |
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| 作者姓名： | 庞霞 郑湘予 李晟磊 赵志华 陈奎生 |
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| 作者单位： | 郑州大学第一附属医院病理科,河南省肿瘤病理承点实验室,郑州,450052 |
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| 基金项目： | 河南省杰出青年科学基金资助项目074100510009;;河南省科技攻关计划基金资助项目082102310011 |
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| 摘 要： | 目的:探讨食管鳞癌(ESCC)组织中半乳糖凝集素-3(Galectin-3)及Bcl-2蛋白的表达及其意义.方法:应用免疫组化SP法检测50例ESCC组织及50例正常食管黏膜组织中Galectin-3与Bcl-2蛋白的表达,并分析ESCC组织中Galectin-3与Bcl-2蛋白表达的关系.结果:ESCC组织及正常黏膜组织中Galectin-3蛋白的阳性表达率分别为72.0%(36/50)和24.0%(12/50),差异有统计学意义(χ2=21.194,P＜0.001);Bel-2蛋白的阳性表达率分别为52.0%(26/50)和6.0%(3/50),差异有统计学意义(χ2=23.507,P＜0.001);Galectin-3和Bel-2蛋白表达均与ESCC的组织学分级和淋巴结转移有关(χ2分别为9.830、7.679和9.933、5.265,P＜0.05).ESCC组织中2者的表达呈正关联(rp=0.357,χ2=7.281,P＜0.001).结论:Galectin-3和Bcl-2蛋白表达与ESCC的发生、发展和转移密切相关,联合检测Galectin-3及Bcl-2蛋白可望成为ESCC早期诊断和预后判断的分子指标之一.
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| 关 键 词： | 食管肿瘤 鳞状细胞癌 半乳糖凝集素-3 Bcl-2 |
Expression of Galectin-3 and Bcl-2 protein in esophageal squamous cell carcinoma tissue |
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| PANG Xia
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ZHENG Xiangyu
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LI Shenglei
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ZHAO Zhihua
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CHEN Kuisheng.Expression of Galectin-3 and Bcl-2 protein in esophageal squamous cell carcinoma tissue[J].Journal of Zhengzhou University: Med Sci,2010,45(1). |
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| Authors: | PANG Xia ZHENG Xiangyu LI Shenglei ZHAO Zhihua CHEN Kuisheng |
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| Institution: | PANG Xia,ZHENG Xiangyu,LI Shenglei,ZHAO Zhihua,CHEN KuishengDepartment of Pathology,the First Affiliated Hospital,Zhengzhou University,Henan Key Laboratory of Tumor Pathology,Zhengzhou 450052 |
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| Abstract: | Aim:To explore the expressions of Galectin-3 and Bcl-2 protein in esophageal squamous cell carcinoma(ESCC) tissue.Methods:Immunohistochemical SP method was used to detect the expressions of Galectin-3 and Bcl-2 proteins in 50 cases of ESCC tissue and 50 cases of normal esophageal epithelium tissue.Results:The positive expression rates of Galectin-3 protein were 72.0%(36/50)and 24.0%(12/50) in carcinoma and normal esophageal epithelium specimens respectively.There was a significant difference between the two... |
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| Keywords: | esophageal neoplasm squamous cell carcinoma Galectin-3 Bcl-2 |
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