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| Management of cholelithiasis in Italian children：A national multicenter study | |
| 引用本文： | Della Corte C,Falchetti D,Nebbia G,Calacoci M,Pastore M,Francavilla R,Marcellini M,Vajro P,Iorio R. Management of cholelithiasis in Italian children：A national multicenter study[J]. World journal of gastroenterology : WJG, 2008, 14(9): 1383-1388. DOI: 10.3748/wjg.14.1383 |
| 作者姓名： | Della Corte C Falchetti D Nebbia G Calacoci M Pastore M Francavilla R Marcellini M Vajro P Iorio R |
| 作者单位： | Claudia Della Carte（Department of Paediatrics,University of Naples "Federico Ⅱ",Via S.Pansini 5,Naples 80131,Italy） ;Diego Falchetti（Department of Pediatric Surgery,"Spedali Civili",Piazza Spedali Civili 1,Brescia 25100,Italy） ;Gabriella Nebbia（Department of Pediatrics Ⅱ,Fondazione IRCCS Ospedale Maggiore di Milano,Via F.Sforza 35,Milan 20122,Italy） ;Marisa Calacoci（Department of Pediatrics,University of Ferrara,Via Savonarola 9,44100 Ferrara,Italy） ;Maria Pastore（Department of Pediatrics,IRCCS "Casa Sollievo della Sofferenza",Viale Cappuccini 1,San Giovanni Rotondo 71013,Italy） ;Ruggiero Francavilla（Department of Pediatrics,University of Bail,Piazza Giulio Cesare 11,Bad 70124,Italy） ;Matilde Marcellini（Department of Pediatrics,Ospedale "Bambin Gesù",Piazza S.Onofrio 4,Rome 00165,Italy） ;Pietro Vajro（Department of Paediatrics,University of Naples "Federico Ⅱ",Via S.Pansini 5,Naples 80131,Italy） ;Raffaele Iorio（Department of Paediatrics,University of Naples "Federico Ⅱ",Via S.Pansini 5,Naples 80131,Italy） ; |
| 摘 要： | AIM：To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition. METHODS： One-hundred-eighty children （90 males, median age at diagnosis 7.3 years; range, 0-18 years） with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers. RESULTS： One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed, but the cholelithiasis recurred in 3 of them. Sixty-five percent of symptomatic children treated became asymptomatic. Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported. Thirty- four children received no treatment and were followed with clinical and echographic controls; in no case thedevelopment of complications was reported. CONCLUSION： The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. |
| 关 键 词： | 小儿科 胆石病 胆囊切除术 意大利儿童 |
| 收稿时间： | 2007-09-21 |
Management of cholelithiasis in Italian children: a national multicenter study |
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| Della Corte Claudia,Falchetti Diego,Nebbia Gabriella,Calacoci Marisa,Pastore Maria,Francavilla Ruggiero,Marcellini Matilde,Vajro Pietro,Iorio Raffaele. Management of cholelithiasis in Italian children: a national multicenter study[J]. World journal of gastroenterology : WJG, 2008, 14(9): 1383-1388. DOI: 10.3748/wjg.14.1383 | |
| Authors: | Della Corte Claudia Falchetti Diego Nebbia Gabriella Calacoci Marisa Pastore Maria Francavilla Ruggiero Marcellini Matilde Vajro Pietro Iorio Raffaele |
| Affiliation: | 1. Department of Paediatrics,University of Naples "Federico Ⅱ",Via S.Pansini 5,Naples 80131,Italy 2. Department of Pediatric Surgery,"Spedali Civili",Piazza Spedali Civili 1,Brescia 25100,Italy 3. Department of Pediatrics Ⅱ,Fondazione IRCCS Ospedale Maggiore di Milano,Via F.Sforza 35,Milan 20122,Italy 4. Department of Pediatrics,University of Ferrara,Via Savonarola 9,44100 Ferrara,Italy 5. Department of Pediatrics,IRCCS "Casa Sollievo della Sofferenza",Viale Cappuccini 1,San Giovanni Rotondo 71013,Italy 6. Department of Pediatrics,University of Bail,Piazza Giulio Cesare 11,Bad 70124,Italy 7. Department of Pediatrics,Ospedale "Bambin Gesù",Piazza S.Onofrio 4,Rome 00165,Italy |
| Abstract: | AIM:To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition.METHODS:One-hundred-eighty children (90 males,median age at diagnosis 7.3 years; range,0-18 years)with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers.RESULTS:One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed,but the cholelithiasis recurred in 3 of them.Sixty-five percent of symptomatic children treated became asymptomatic.Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported.Thirty-four children received no treatment and were followed with clinical and echographic controls; in no case the development of complications was reported.CONCLUSION:The therapeutic strategies were extremely heterogeneous.Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms.Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. |
| Keywords: | Pediatric cholelithiasis Ursodeoxycholic acid Laparoscopic cholecystectomy Gallstones Children |
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