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新目安眼用凝胶剂与目安眼用凝胶剂体外释药特性比较研究
引用本文:肖海英,郭畅,何群,陈光宇,王适,赵碧清,黄略.新目安眼用凝胶剂与目安眼用凝胶剂体外释药特性比较研究[J].中国药师,2014(4):574-578.
作者姓名:肖海英  郭畅  何群  陈光宇  王适  赵碧清  黄略
作者单位:湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;长沙医学院药学系;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;;湖南中医药大学 湖南省教育厅药学“十二五”重点学科 长沙 410208;
基金项目:湖南省自然科学基金项目(编号:11JJ3107)
摘    要:目的:探索更昔洛韦替代阿昔洛韦组成的新目安眼用凝胶剂体外释药性能是否优于原目安眼用凝胶剂。方法:以更昔洛韦含量,阿昔洛韦含量为指标,采用桨法2(《中国药典》方法),进行体外释药试验。结果:新目安眼用凝胶剂释药特性等同于目安眼用凝胶剂,释药速度相似,释药量相同,皆达到或满足临床用药目的,凝胶基质对药物释放无影响,该基质能快速将药物释放出来溶解于泪液中发挥治疗作用。结论:新目安眼用凝胶剂释药特性符合眼用制剂需求。更昔洛韦替代阿昔洛韦组成的新目安眼用凝胶剂体外释药性能等同于原目安眼用凝胶剂,给药次数及间隔时间基本科学,合理,可行,并为下一步药效,毒理,临床研究提供依据。

关 键 词:新目安眼用凝胶剂  目安眼用凝胶剂  更昔洛韦  阿昔洛韦  体外释药
收稿时间:2013/9/17 0:00:00
修稿时间:2013/12/13 0:00:00

Comparative Study of the Character of Release in vitro between New MU-AN Ophthalmic Gel and the Old
Xiao Haiying,Guo Chang,He Qun,Chen Guangyu,Wang Shi,Zhao Biqing,Huang Lue.Comparative Study of the Character of Release in vitro between New MU-AN Ophthalmic Gel and the Old[J].China Pharmacist,2014(4):574-578.
Authors:Xiao Haiying  Guo Chang  He Qun  Chen Guangyu  Wang Shi  Zhao Biqing  Huang Lue
Institution:1. Hunan University of Chinese Med- icine, Pharmaceutical "Twelfth Five-Year Plan" Key Disciplines of Department of Education of Hunan Province, Changsha 410208, China;2. Department of Pharmacy, Changsha Medical College)
Abstract:Objective: To search the release in vitro of new MU-AN ophthahnic gel consist of ganciclovir instead of aciclovir is whether better than the Old. Methods: Using the content of ganciclovir and acyclovir as the index, taking the second oar method ( in Ch. P 2010) , drug release in vitro test was investigated. Results: The character of drug release of new MU-AN ophthalmic gel was e- qual to the old, the rate of drug release was similar, The amount of drug release was the same. Both drugs met the requirements of clin- ical medication. The character corneal permeability of new MU-AN ophthalmic gel was better than the old. Gel matrix had no influ- ences on drug release, drug would be bring treatment effect after the way that it was released quickly then was dissolved in tear. Con- clusion: The drug release characteristics consistent with ophthalmic preparation requirements. The character of drug release of new MU-AN ophthalmic gel consist of ganciclovir instead of aciclovir is equal to the old, the time administer drug and interval time is gener- ally scientific, reasonable and feasible, providing the basis for the pharmacodynamics , toxicology and clinical study in the next step.
Keywords:New MU-AN ophthalmic gel  MU-AN ophthahnic gel  Ganciclovir  Acyelovir  Drug release in vitro
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