妥洛特罗贴剂佐治毛细支气管炎的临床研究

目的：观察妥洛特罗贴剂治疗毛细支气管炎的临床疗效及不良反应,评价其对毛细支气管炎治疗作用。方法：160例毛细支气管炎患儿按随机数字表法随机分成观察组（n=80）和对照组（n=80）,两组给予氧疗,布地奈德气雾剂雾化吸入,抗感染等常规治疗,对照组在常规治疗基础上应用沙丁胺醇气雾剂雾化吸入,而观察组应用妥洛特罗贴剂；观察两组病例的临床症状、体症消失时间及住院天数及不良反应。结果：观察组咳嗽消失时间为（5.08±2.35） d,哮鸣音消失时间为（3.26±1.87）d,住院天数为（6.15±2.27）d,不良反应率为3.75%。对照组咳嗽消失时间为（6.75±2.47）d,哮鸣音消失时间为（5.50±1.78）d,住院天数为（7.59±2.11）d,不良反应率为38.75%。与对照组比较,观察组的临床症状、体征消失的时间及住院时间短,不良反应少,差异有统计学意义（P〈0.05）。结论：妥洛特罗贴剂佐治毛细支气管炎,可提高临床疗效,方便易执行,安全可靠。

Clinical Study on Adjuvant Treatment of Capillary Bronchitis by Tulobuterol Patches

Objective：To observe the effects and adverse reactions of tulobuterol patches in the adjuvant treatment of capillary bronchitis to elucidate the treatment effect of tulobuterol patches in the patients with capillary bronchitis. Methods：A total of 160 chil-dren with capillary bronchitis were randomly divided into the observation group and the control group. Both groups were given conven-tional therapy：oxygen treatment, aerosol inhalation of budesonide and anti-infection, etc. The control group was given nebulized al-buterol aerosols additionally, while the observation group was received tulobuterol patches additionally. The disappearance time of clini-cal symptoms and signs, the average length of stay in hospital and the incidence of adverse reactions between the two groups were com-pared. Results：In the observation group, the symptom of cough disappeared in （5. 08 ± 2. 35） d, wheezing disappeared in （3. 26 ± 1. 87）d, and the hospitalization time was （6. 15 ± 2. 27） d. Compared with those in the control group, the above indices were all shor-ter with statistically significant difference （P〈0. 05）. The incidence of adverse reactions was 3. 75% in the observation group while 38. 75% in the control group, the difference was statistically significant（P〈0. 05） . Conclusion：Tulobuterol patches in the adjuvant treatment of capillary bronchitis can improve the clinical curative effect with promising safety and practicability.