Relationship between use of proton pump inhibitors and IGF system in older subjects |
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Authors: | Marcello Maggio F. Lauretani F. De Vita V. Butto C. Cattabiani S. Masoni E. Sutti G. Bondi E. Dall’Aglio S. Bandinelli A. Corsonello A. M. Abbatecola F. Lattanzio L. Ferrucci G. P. Ceda |
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Affiliation: | 1. Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Parma, Italy 2. Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy 7. Department of Clinical and Experimental Medicine, Geriatric Clinic, Food Sciences Unit and Endocrinology of Aging Unit, via Gramsci 14, 43100, Parma, Italy 3. Azienda Sanitaria Firenze, Florence, Italy 4. Unit of Geriatric Pharmacoepidemiology, Italian National Research Centres on Aging (INRCA), Cosenza, Italy 5. Italian National Research Centres on Aging (INRCA), Ancona, Italy 6. National Institute on Aging, National Institutes of Health, Baltimore, USA
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Abstract: | Objectives to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly. Design cross-sectional. Setting InCHIANTI study. Participants 938 older subjects (536 women, 402 men, mean age 75.7±7.4 years). Measurements complete data on age, sex, BMI, liver function, medications, dietary intake, IGF-1, IGF-binding protein-1 and -3 (IGFBP-1, IGFBP-3). Results Participants were categorized by PPI use, identifying 903 PPI non users and 35 users. After adjusting for age, male PPI users (107.0 ± 69.6 vs 127.1 ± 55.8, p<0.001) and female PPI users (87.6 ± 29.1 vs 107.6 ± 52.3, p=0.03) had lower IGF-1 levels than non-users. IGFBP-1 levels were similar in the two groups in both sexes. In whole population, after adjustment for age and sex, PPI users had lower IGF-1 levels 81.9 [61.1–113.8] than nonusers 110 [77.8–148.6], p=0.02. After further adjustment for BMI, albumin, liver function, C-reactive protein, Interleukin-6, number of medications, ACE-inhibitors use, caloric intake, protein intake, physical activity, glycemia, and IGFBP-1, the use of PPIs remained significantly and negatively associated with IGF-1 levels (β±SE=?19.60±9.83, p=0.045). Conclusion Use of PPIs was independently and negatively associated with IGF-1 levels. |
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