“一测多评”测定木香顺气丸中木香内酯类成分

目的 建立“一测多评”法测定木香顺气丸中2种木香内酯类成分的高效液相色谱分析方法，使之更有效的控制其质量。方法 以木香烃内酯为内标，建立其与去氢木香内酯的相对校正因子，用高效液相色谱法进行含量测定，计算木香烃内酯、去氢木香内酯的含量，对“一测多评”法的计算值与外标法实测值进行比较。结果 建立的相对校正因子重现性良好，采用相对校正因子计算的含量与外标法实测值无显著性差异。结论 “一测多评”法可用于木香顺气丸中木香内酯类成分的含量测定，方法可靠，结果准确，能有效控制该制剂质量。

Determination of Costuslactone in Muxiang Shunqi Pills By QAMS

OBJECTIVE To establish a method for determinaion of two costuslactone in Muxiang Shunqi pills by quantitative analysis of multi-components by single marker(QAMS) for more perfect quality. METHODS Taking costunolide, as reference, a relative correction factor(RCF) of dehydrocostuslactone was established. Then the RCF was used to calculate the contents of the dehydrocostuslacton. In this way, the calculated value was compared with the external standard method. RESULTS No significant differences were found in the quantitative analysis results of dehydrocostuslacton between external standard method and QAMS method. CONCLUSION The described method is reliable, accurate, and can be used to control the quality of costuslactone of Muxiang Shunqi pills.