早期运用苯巴比妥钠预防新生儿窒息后脑损伤

目的 探讨早期干预对新牛儿室息后脑损伤发病率的影响。方法 对出生时有室息表现的新生儿存在出生后6h内给予笨巴比妥钠15mg／kg，12h后给予5mg／kg，每12小时一次，维持3～5d。结果 预防朋药组较对照组往新生儿窒息后的缺氧缺血性脑病、颅内出血等脑损伤的发病率有明显降低，两者相比较有显著差异（P〈0．05）。结论 对出生时有窒息表现的新生儿可以使用苯巴比妥钠进行早期干预。

Early application of sodium phenobarbital in the prevention of brain injury following asphyxiation in neonates

Objective To explore the treatment effect of sodium phenobarbital on cerebral injury of neonates with asphyxiation. Methods The neonates who had asphyxiation were given with 15 mg/kg within 6 h after birth, 5 mg/kg after 12 h, twice a day, for 3~5 d. Results The incidence rate of cerebral injury, such as hypoxic-ischemic encephalopathy and intracranial hemorrhage, in the prevention group is lower than that in the control group. There was significant difference between the two groups (P<0.05). Conclusion It is advisable to treat the neonates with asphyxiation early with sodium phenobarbital.