aDepartment of Psychobiology, University of California, Irvine, CA 92717, U.S.A.
Abstract:
6-Hydroxydopamine injections along mesostriatal dopaminergic axons can be used to interrupt axonal transport from cell bodies in the substantia nigra pars compacta to terminal fields in the striatum. Such lesions produce accumulations of high-affinity dopamine uptake sites (as measured by 3H]mazindol binding) and acetylcholinesterase proximal to the injection, suggesting that at least a portion of the 3H]mazindol binding and acetylcholinesterase activity seen in the striatum is located presynaptically on the mesostriatal dopaminergic fibers.