亚低温治疗重型颅脑损伤的临床疗效观察

目的分析亚低温治疗对重型颅脑损伤的临床疗效。方法将78例重型颅脑损伤患者随机分为两组，每组39例。对照治疗组采用降颅内压、营养脑细胞、预防感染、营养支持、维持水电解质及酸碱平衡等对症支持治疗，亚低温治疗组在对照治疗组常规综合治疗的基础上加用亚低温疗法。所有患者均随访6个月评价预后。结果78例病人治疗结束后，根据伤后6个月评价预后，亚低温治疗组39例患者中，恢复良好23例，中残7例，重残及植物生存3例，死亡6例。对照治疗组39例患者，恢复良好11例，中残5例，重残及植物生存10例，死亡13例。亚低温治疗组疗效明显优于对照治疗组（P〈0．05）。结论亚低温治疗能改善重型颅脑损伤患者预后，提高生存质量，降低死亡率。

Clinical Effect Observation of Sub-Hypothermia in the Treatment of Severe Craniocerebral Injury

Objective To analyze the clinical craniocerebral injury. Methods 78 patients with efficacy of sub-hypothermia therapy in the treatment of severe severe craniocerebral injury were randomly divided into two groups. Each group had 39 cases. The control group received symptomatic treatments, which including the reduction of intracranial pressure, nourishment of brain cells, infection prevention, nutrition support, restoration of water- electrolyte and acid-base balances. The treatment group were given sub-hypothermia therapy in addition to the afore-mentioned conventional treatments. All patients were followed up after the treatment for 6 months to evaluate their outcomes. Results Among the 39 patients in the sub-hypothermia group, 23 cases were achieved desirable rehabilitation, 7 cases were moderate handicapped, 3 cases were severely disabled or plant survival, and 6 cases died. While in the control group, l l cases recovered well, 5 cases were moderate handicapped, 10 cases were severely disabled or plant survival, and 13 eases died. The efficacy of sub-hypotherrnia group was obviously better than the control group （P〈0.05）. Conclusion The sub-hypothermia therapy can improve the prognosis of patients with severe craniocerebral injury contributes, improve quality of life and reduce mortality.