咖啡酸阿魏酸对高血压大鼠的降压作用

目的：研究桂皮酸类化合物咖啡酸和阿魏酸对高血压大鼠的降压作用及作用机理。方法：口服咖啡酸与阿魏酸对DOCH高血压大鼠血压的影响，对DOCA高血压动物血浆ET-l浓度、血压、心血管组甥增生及ET-1、c—fos、HSP70 mRNA基因表达的影响；对ET-1引起的正常大鼠血压上升的对抗作用。结果：咖啡酸和阿魏酸静昧注射能降低ET-1引起的正常大鼠血压上升；咖啡酸和阿魏酸长期口服给药能降低DOCA高血压模型大鼠的血压．对心脏和血管组织增生有明显的抑铽作用，可降低血浆中ET-1的浓度．并可减少ET-1引起的c-fos、HSP70 mRNA基因表达的增加。结论：咖啡酸和阿魏酸可通过拮抗ET-1的作用降低血压。

HYPOTENSIVE EFFECTS OF CAFFEIC ACID AND FERULIC ACID IN DOCA-SALT HYPERTENSIVE RATS

AIM The antagonistic effects cinnamic acid compounds caffeic acid and ferulic acid on endothelin-1 (ET-1) biological responses,and the antagonistic mechanism of elevation of blood pressure on ET-1 were in vestigated in DOCA-salt hypertensive and normotensive rats.METHODS Blood pressure body weight,cardiovascular tissues wet weight,gene expression of ET-1,c-fos and HSP70 mRNA,plasma levels of ET-1,and 125 I ET-1 binding with 3T3 cells were determined in DOCA-salt hypertensive rats and nor mofensive rats.RESULTS Intraperitoneal injection of Caffeic acid and ferulic acid could increase the survival time after acute death induced by ET-1,blunt the elevation of blood pressure on normotensive rats markedly by ET-1 intravenously,and dilate the vasoconstriction of isolated aortic rings,blunt the elevation of systolic blood pressure and development of cardiovascular hypertrophy in DOCA-salt hypertensive rats,inhibit gene expression of ET-1,c-fos, HSP70 mRNA and decrease the plasma levels of ET-1.CONCLUSION Caffeic acid and ferulic acid are new non-peptide ET-1 antagonists.