C反应蛋白在冠状动脉临界病变患者危险评估中的作用

目的探讨血清C反应蛋白（CRP）水平在冠状动脉临界病变患者危险评估中的作用。方法选择93例经冠状动脉造影提示临界病变的患者，测定其血清CRP，并按CRP水平分为两组：A组（CRP〈3mg／L，46例），B组（CRP〉3mg／L，47例），统计比较两组患者的发病诊断（稳定型心绞痛和不稳定型心绞痛）比率及1年内心血管事件（包括顽固性心绞痛药物治疗无效而行介入治疗、非致死性心肌梗死、新发心律失常、新出现心力衰竭、心源性死亡）的发生率。结果93例患者中以不稳定心绞痛发病的患者共有65例，A组有27例患者以不稳定心绞痛来院就诊．B组有38例患者以不稳定型心绞痛来院就诊；随访1年期间A组出现心血管事件共8例，B组共17例，B组心血管事件发生率高于A组（P〈0．05）。结论临界病变患者多数以不稳定心绞痛为首发．血清C反应蛋白可作为评估冠状动脉临界病变患者风险的可靠指标。

Role of C-reactive protein in patients with coronary artery disease risk assessment of the critical

Objective To study the value of CRP (C-reactive protein) in patients with coronary artery disease risk assessment in the critical.Methods Ninety-three angina petients with critical lesion of coronary stenosis confirmed by coronay angiography were assigned to A group (CRP<3 mg/L,n=46) and B group (CRP>3 mg/L,n=47) based on the serum CRP levels.Compared two groups of patients with disease diagnosis (stable angina and unstable angina),and the incidence of cardiovascular events (including refractory angina drug therapies and interventional treatment of non-fatal myocardial infarction,arrhythmia new hair,new heart failure,cardiac death) within 1 year.Results A total of 65 cases with onset in 93 patients with unstable angina,27 patients to hospital with unstable angina in A group,38 patients to hospital with unstable angina in B group,one year follow-up,A group occurred eight cardiovascular events,B group occurred seventeen cardiovascular events,which in B group was significantly increased compared with that of B group (P< 0.05).Conclusion Most of the critical lesions in patients with unstable angina onset,C-reactive protein is a critical assessment of coronary artery disease in patients with a reliable indicator of risk.