儿童哮喘急性发作时血清C反应蛋白的变化

目的探讨检测血清C反应蛋白在儿童哮喘急性发作时诊断、预测以及治疗中的临床意义。方法选择2009～2010年来本院就诊的支气管哮喘儿童患者112例作为病例研究组，以同期120例正常儿童作为对照组。分别于糖皮质激素治疗前后进行血浆CRP测定和白细胞计数。结果支气管哮喘急性发作组与正常对照组间比较，白细胞计数和血浆CRP有显著升高，P〈0．01；支气管哮喘急性发作组治疗前与治疗后相比，白细胞计数有显著减少．同时血浆CRP浓度也显著减少，P〈O．01。结论血浆CRP不仅是一种潜在的支气管哮喘患者急性发作的标志物，同时可作为支气管哮喘急性发作治疗效果的一种评判指标。

Changes of serum C-reactive protein in acute attack of children with asthma

Objective To investigate the clinical significance of the detection of serum C-reactive protein(CRP) in the diagnosis,prediction and treatment of acute attack of pediatric asthma.Methods One hundred and twelve pediatric patients with bronchial asthma admitted to our hospital from 2009 to 2010 were chosen as study group,and 120 normal children in the same period were chosen as control group.Determination of plasma CRP and leukocyte count before and after treatment of glucocorticoid were assessed respectively.Results Compared with control group,the white blood cell count and plasma CRP in the study group were increased significantly(P < 0.01);compared with before treatment,the leukocyte count and the concentration of plasma CRP after treatment in the study group were reduced significantly(P < 0.01).Conclusion Plasma CRP is not only a potential marker for children with bronchial asthma,but also an evaluation index for the treatment effect of acute attack of pediatric asthma.