2型糖尿病患者合并下肢动脉硬化闭塞症相关危险因素分析

目的通过分析比较2型糖尿病合并下肢动脉硬化闭塞症（LEASOD）和无下肢动脉硬化闭塞症（NLEASOD）的两组患者的相关影响因素,找出引起LEASOD发病的危险因素。方法选择109例2型糖尿病患者作为研究对象,分为51例合并LEASOD做为病例组,58例NLEASOD的患者为对照组。采用回顾性病例对照研究的方法,分别对病例组和对照组患者收集与LEASOD发病密切相关的影响因素。结果单因素Logistic回归分析结果显示年龄、吸烟史、病程、高血压（HBP）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、空腹C肽（FCP）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、脂蛋白α（Lpα）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、血尿酸（BUA）,合并冠心病（CHD）、糖尿病性周围神经病变（DPN）在病例组和对照组之间表现出与LEASOD发病有不同程度的正相关（P〈0.05）。在随后的多因素非条件Logistic回归分析中,年龄、吸烟史、病程、HBP、FPG、HbA1c、FCP、TG、TC、LDL-C、Lpα、ApoA1、ApoB、CHD、DPN作为相关影响因素被选入（P〈0.05）。结论 ApoB、LDL-C、DPN、CHD为LEASOD发病的突出危险因素。

The analysis of risk factors correlated with lower extremity arteriosclerosis occlusive disease of type 2 diabetic patients

Objective Through analyzed and compared the related influencing factors between the two groups of type 2 diabetes with lower extremity arteriosclerosis occlusive disease(LEASOD) and no lower extremity arteriosclerosis occlusive disease(NLEASOD),to find out the risk factors of LEASOD.Methods Chose 109 cases of type 2 diabetes patients as the research object,divided into 51 cases LEASOD as merger case group,58 cases NLEASOD of patients for the control group.The retrospective case control study method respectively,the case group and control group patients were closely related to collect and LEASOD influence factors.Results Univariate Logistic regression analyzed had showed that these factors included age,smoking,course of disease,HBP,FPG,HbA1c,FCP,TG,TC,HDL-C,LDL-C,Lpα,ApoA1,ApoB,BUA,patients combined with CHD,DPN were different,and the varying degrees were positive correlation(P < 0.05).In subsequent multivariate unconditional Logistic regression analysis,age,smoking history,course of the disease,HBP,FPG,HbA1c,FCP,TG,TC,LDL-C,Lpα,ApoA1,ApoB,CHD,DPN were selected as the related factors(P < 0.05).Conclusion ApoB,LDL-C,DPN,CHD are the prominent risk factors in LEASOD.