茶多酚对慢性肾功能衰竭患者脂质过氧化损伤的影响

目的：探讨茶多酚在治疗慢性肾功能衰竭（ＣＲＦ）中抗脂质过氧化及改善肾功能的作用。方法：观察３１例ＣＲＦ患者（治疗组）用海南省茶多酚（ＴＰ）治疗前及治疗后３个月的红细胞超氧化物歧化酶（ＳＯＤ）、还原型谷胱甘肽（ＧＳＨ）、血浆丙二醛（ＭＤＡ），血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ），血尿素氮（ＢＵＮ）和血肌酐（ＳＣｒ）含量变化。另以未经ＴＰ治疗的２０例ＣＲＦ患者为对照组，并与８９例健康成人的ＳＯＤ、ＧＳＨ和ＭＤＡ作比较。结果：治疗组及对照组ＣＲＦ患者ＳＯＤ活性明显低于健康成人（Ｐ均＜０．０１），ＭＤＡ及ＧＳＨ高于健康成人（Ｐ均＜０．０５）；治疗后治疗组ＳＯＤ活性明显升高，ＭＤＡ、ＴＣ、ＴＧ、ＢＵＮ和ＳＣｒ均有降低，与对照组比较差异均显著（Ｐ均＜０．０５）。肾功能改善总有效率前者为６７．７４％，后者为３０．００％。结论：ＣＲＦ患者确实存在ＳＯＤ活性降低及脂质过氧化损伤，海南省茶多酚能有效对抗脂质过氧化，提高氧化酶ＳＯＤ活性，改善ＣＲＦ患者肾功能。

Influences of tea polyphenols on impairments induced by lipid peroxide in patients with chronic renal failure

Objective:To investigate the actions of tea polyphenols (TP) on antagonizing lipid peroxide and improving renal functions in treatment for chronic renal failure (CRF).Methods:The changes in concentrations of erythrocytic superoxide dismutase(SOD),glutathione hormone(GSH),plasma malondialdehyde(MDA),serum total cholesterols (TC),triglyceride (TG),blood urea nitrogen(BUN),and serum creatinine(SCr) were observed in 31 cases with CRF before and after therapy with TP of Hainan province.Otherwise 20 cases with CRF didn't be treated with TP as control group and compared with 89 healthy adults in levels of SOD,GSH,and MDA.Results:In patients with CRF of treatment and control group the activities of SOD were significantly lower than those in healthy adults (all P <0 01);the levels of MDA and GSH were higher than those in healthy adults (all P <0 05).After therapy the activities of SOD were significantly increased meanwhile all the MDA,TC,TG,BUN and SCr were decreased in treatment group.Comparing with control group,there were significant differences (all P <0 05).The total effective rates for improving renal functions were 67 74% in the former and 30 00% in the latter.Conclusions:The depression of SOD activities and the impairment of lipid peroxide are really existed in patients with CRF.TP of Hainan province is able to antagonize lipid peroxide effectively,increase the activities of SOD,and improve renal functions in patients with CRF.