| The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro |
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| 引用本文： | Wanli Liu,Zhongyao Wu Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China. The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro[J]. 眼科学报, 2005, 21(1): 62-67 |
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| 作者姓名： | Wanli Liu Zhongyao Wu Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China |
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| 作者单位： | Wanli Liu，Zhongyao Wu Zhongshan Ophthalmic Center，Sun Yat-sen University，Guangzhou 510060，China |
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| 摘 要： | Purpose: To study cyelosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs. Methods : To study the growth curve of cyelosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyelosporine A combined with seven antineoplastic drugs. Results: The average IC50 of cyelosporine A on the 27 retinoblastoma cells is 67.81μg/ ml and the average inhibitive rate of these samples is 26.1% when cyelosporine A is in the concentration of 2μg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyelosporine A and the increasing average inhibitive rate is more than 5. Conclusion: Cyelosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells. Eye Science 2005;21;62-66.
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| 关 键 词： | 眼肿瘤 抗肿瘤药物 环孢霉素A 药物治疗 |
The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro |
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| Wanli Liu,Zhongyao Wu. The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro[J]. Eye science, 2005, 21(1): 62-67 |
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| Authors: | Wanli Liu Zhongyao Wu |
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| Affiliation: | Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China |
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| Abstract: | PURPOSE: To study cyclosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs. METHODS: To study the growth curve of cyclosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyclosporine A combined with seven antineoplastic drugs. RESULTS: The average IC50 of cyclosporine A on the 27 retinoblastoma cells is 67.81microg/ ml and the average inhibitive rate of these samples is 26.1% when cyclosporine A is in the concentration of 2microg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyclosporine A and the increasing average inhibitive rate is more than 5. CONCLUSION: Cyclosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells. |
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| Keywords: | retinoblastoma cyclosporine A MTT assay |
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