| Abstract: | Experiments on cats in which electromagnetic and resistographic methods were used showed that sodium hydroxybutyrate (100 mg/kg) considerably increases the cerebral circulation. It also increases the blood flow into the brain during the period of formation of pressor blood pressure reflexes. An increase in blood flow also is observed in the system of the femoral arteries, whereas in the intestinal artery, on the other hand, the increase in the blood flow is reduced during vasomotor reflexes. Reflex changes in the resistance of the regional vessels also differ in character: depression of pressor reflexes in the cerebral vessels accompanied by facilitation in the intestinal and femoral arteries and potentiation of the dilator phase of the reflex in the limb vessels. These differences are evidently based on differences in the sensitivity of sympathetic formations in the central components of the different regional vasomotor reflexes to hydroxybutyrate.Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 11, pp. 555–557, November, 1979. |
