软骨损伤的基因治疗研究进展

由于软骨组织内无血管,因此其损伤后仅靠其自身来修复是非常有限的。有研究表明,很多细胞因子具有促进软骨形成及软骨样组织修复的功能。由细胞介导的相关基因于损伤部位分泌这些细胞因子促进软骨修复被认为是最理想的治疗方法。基因治疗正是在这一基础上发展起来的一种治疗技术,近年来取得了快速的发展。就近期软骨损伤的基因治疗进展进行综述。

Advances in the research of gene therapy for chondral lesions

Cartilage injury has a very limited capacity of recovery by itself due to the lack of blood vessel in cartilage tissues. Current studies indicate that many kinds of cytokines have the function of promoting cartilage formation or repairing the injured cartilage with cartilage-like tissues. Cell-mediated transfer of the respective genes may ideally combine the supply of a chondrogenic cell population with the production of certain factors se-creted from the lesion and to promote the repairing of the lesion, which is considered the best treatment. Gene therapy based on this technology has developed rapidly in recent years. This review aims to summarize some of the development of the research in the field.