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| 血管紧张素Ⅱ-1型受体基因A1166→C多态性与冠心病关联的研究 | |
| 引用本文： | 刘瑞,陈玉成,白怀,李献,刘宇,邓珏琳,刘秉文.血管紧张素Ⅱ-1型受体基因A1166→C多态性与冠心病关联的研究[J].四川大学学报(医学版),2002,33(4):533-535. |
| 作者姓名： | 刘瑞 陈玉成 白怀 李献 刘宇 邓珏琳 刘秉文 |
| 作者单位： | 1. 四川大学华西医院,内科实验室,成都,610041 2. 四川大学华西医院,心内科 3. 四川大学,载脂蛋白研究室 |
| 基金项目： | 教育部留学回国人员科研基金资助 |
| 摘 要： | 目的探讨血管紧张素Ⅱ-1型受体(AT1R)基因A1166→C多态性与冠心病的关系. 方法应用多聚酶链反应(PCR)对成都地区汉族133例正常对照及113例冠心病患者(其中52例伴有高血压)的AT1R基因A1166→C多态性进行分析.结果冠心病患者的C等位基因频率与正常对照组比较无显著性差异(0.066 vs 0.075, P>0.05).冠心病伴有高血压组的C等位基因频率与未伴有高血压组的C等位基因频率比较,有降低趋势(0.038 vs 0.090,P=0.09).冠心病伴有高血压组与正常对照组比较,C等位基因频率也有降低趋势(0.038 vs 0.075,P=0.14).结论 AT1R基因A1166→C多态性与冠心病无关联, AT1R基因A1166→C多态性与原发性高血压的发生可能有一定关联. |
| 关 键 词： | 冠心病 血管紧张素Ⅱ-1型受体基因 限制性片段长度多态性 |
| 修稿时间： | 2001年11月23 |
Association Between Angiotensin Ⅱ Type 1 Receptor Gene A1166→C Polymorphism and Coronary Heart Disease in Chinese |
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| Liu Rui ,Chen Yucheng,Bai Huai,Li Xian,Liu Yu,Deng Juelin,Liu Bingwen. Laboratory of Internal Medicine,West China Hospital,Sichuan University,Chengdu ,China.Association Between Angiotensin Ⅱ Type 1 Receptor Gene A1166→C Polymorphism and Coronary Heart Disease in Chinese[J].Journal of West China University of Medical Sciences,2002,33(4):533-535. | |
| Authors: | Liu Rui Chen Yucheng Bai Huai Li Xian Liu Yu Deng Juelin Liu Bingwen Laboratory of Internal Medicine West China Hospital Sichuan University Chengdu China |
| Institution: | Liu Rui *,Chen Yucheng,Bai Huai,Li Xian,Liu Yu,Deng Juelin,Liu Bingwen. *Laboratory of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,China |
| Abstract: | Objective To investigate the association between AT 1R gene polymorphism and coronary heart disease in Chinese population. Methods The restriction fragment length polymorphisms (RFLPS) at A 1166 /C polymorphism of AT 1R gene were detected using PCR in 113 coronary heart disease (CHD) patients (52 with hypertension) and 133 healthy subjects from a population of Chinese Hans in Chengdu area. Results There was no difference in C allele frequency between CHD group and control group (0.066 vs 0.075, P >0.05). In addition, in CHD with hypertension group, the C allele frequency showed a tendency to be lower when compared with CHD without hypertension group (0.038 vs 0.090, P =0.09). In CHD with hypertension group, the C allele frequency also tended to be lower when compared with control group (0.038 vs 0.075, P =0.14). Conclusions No significant association between A 1166 /C polymorphism of AT 1R gene and CHD is confirmed in this study. The results suggest that there may be an association between the A 1166 /C polymorphism and primary hypertension in Chinese. |
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