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肝内胆管结石动物模型的实验研究
引用本文:邹声泉,裘法祖,于昌松. 肝内胆管结石动物模型的实验研究[J]. 华中科技大学学报(医学版), 1989, 0(2)
作者姓名:邹声泉  裘法祖  于昌松
作者单位:同济医科大学附属同济医院外科(邹声泉,裘法祖),同济医科大学附属同济医院外科(于昌松)
摘    要:为研制肝内胆管结石模型,将实验兔分为4组:①正常对照组,②单纯胆总管内注菌组,③单纯胆总管结扎组,④胆总管结扎加注菌组。实验结果显示,第1、2组均未形成结石,第4组的成石率为60.0%,明显高于第3组(25.0%)。结石实验兔的受累肝脏和胆道系统均有不同程度的化脓性变化,胆汁成分有明显改变,讨论了其对结石的影响。

关 键 词:肝内胆管结石  胆汁  模型  外科

Experimental Study on the Formation of Intrahepatic Calculi in Animal Model
Zhou Shenquan,Qiu Fazu,Yu Changsong. Experimental Study on the Formation of Intrahepatic Calculi in Animal Model[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1989, 0(2)
Authors:Zhou Shenquan  Qiu Fazu  Yu Changsong
Affiliation:Zhou Shenquan,Qiu Fazu,Yu Changsong Department of Surgery,Tongji Hospital,Tongji Medical University,Wuhan
Abstract:In order to establish an animal model of intrahepatic calculi, rabbits were divided into 4 experimental groups:(l)normal controls, (2) bacteria injected into the common duct, (3) simple ligation of the common duct,(4)ligation of the common duct with bacteria injected. The results showed that, stones were produced in groups 3 and 4, the rate of stone formation in group 4 (60%) was higher than in group 3 (25%). Purulent changes in various degree were demonstrated in the affected portions of the hepatobiliary system, and the influence of these changes upon the stone formation process is discussed.
Keywords:intrahepatic calculi  bile  cast  surgical
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