BCSG1、c-erbB-2、VEGF表达与乳腺癌临床病理因素相关性研究

目的研究乳腺癌组织中乳腺癌特异基因1(BCSG1)、人表皮生长因子受体-2(c-erbB-2)、血管内皮生长因子(VEGF)分别及联合表达情况与临床病理学特征的关系。方法随机抽取316份临床病理资料完整的乳腺癌标本,采用免疫组化S-P法检测BCSG1、c-erbB-2、VEGF的表达情况,并结合临床病理特征进行分析。结果乳腺癌组织BCSG1、VEGF阳性表达率分别为67.1%、61.0%,均与组织学分级、淋巴结转移、临床分期呈正相关(分别为r=0.152、r=0.510、r=0.460及r=0.166、r=0.142、r=0.142,P<0.05,P<0.01),与ER、PR、肿瘤大小、月经状况、病理类型无关(P>0.05);c-erbB.2阳性表达率32.2%,与肿瘤大小、组织学分级、淋巴结转移、临床分期呈正相关(r=0.173、r=0.157、r=0.365、r=0.306,P<0.01);与ER、PR呈负相关(r=-0.149,r=-0.154,P<0.05),与月经状况、病理类型无关(P>0.05);BCSG1、c-erbB-2、VEGF共同表达与淋巴结转移、临床分期、组织学分级呈正相关(r=0.457、r=0.377、r:0.228,P<0.05);BCSG1、c-erbB-2、VEGF之间两两表达呈正相关(P<0.01)。结论 BCSG1、c-erbB-2、VEGF的表达与乳腺癌发生、发展及侵袭转移有关,三者同时高表达提示肿瘤具有更高的侵袭转移能力。

Expressions of BCSG1,c-erbB-2 and VEGF in breast cancer and correlation with clinical-pathological features

Objective To evaluate the expression of BCSGl,c-erbB-2,VEGF in human breast carcinoma and the relationship with clinical-pathological features.Methods By immunohistochemical S-P method,the expressions of BCSG1,cerbB-2 and VEGF were examined in 316 breast cancer specimens,the correlation between these indexes and clinical-pathologi cal features were analyzed.Results BCSG1 and VEGF positive rate were 67.1%and 61.0%.The expression of BCSG1 and VEGF were both positively correlated with histological grade,lymph node metastasis and clinical stage(r=0.152,r= 0.510,r =0.460 andr =0.166,r =0.142,r =0.142,P < 0.05,P <0.01),and both independence with ER,PR, tumor size,menstruation,pathology type(P>0.05).C-erbB-2 positive rate was 32.2%,the expression of c-erbB-2 was positively correlated with tumor size,histological grade,lymph node metastasis and clinical stages(r =0.173,r =0.157, r=0.365,r=0.306,P<0.01),but negatively correlated with ER,PR expressions(r=-0.149,r=-0.154,P< 0.05),and independence with menstruation and pathology type(P>0.05).The co-expression of these three proteins positively correlated with lymph node metastasis,clinical stages and histological grade,(r=0.457,r=0.377,r=0.228,P< 0.05).The expression of BCSG1,c-erbB-2 and VEGF were all positively correlated with each other(P<0.01).Conclusion The expression of BCSG1,c erbB 2 and VEGF were correlated with carcinogenesis of breast cancer nd development.The high co-expression of the three proteins predicts strong aggression and metastasis ability.