| 硝苯地平亲水凝胶骨架缓释片的体内外相关性研究 |
| |
| 引用本文： | 陈军,尹伟. 硝苯地平亲水凝胶骨架缓释片的体内外相关性研究[J]. 临床医学工程, 2012, 19(3): 345-347 |
| |
| 作者姓名： | 陈军 尹伟 |
| |
| 作者单位： | 陈军 (南京中医药大学研究生院,江苏南京,210046) ； 尹伟 (安徽新华学院药学院,安徽合肥,230038) ； |
| |
| 摘 要： | 目的对硝苯地平亲水凝胶骨架片的体内外相关性进行研究。方法采用自制硝苯地平亲水凝胶骨架片,分别考察其体外释放度和大鼠体内药物释放行为,采用反卷积分法考察其体内外相关性。结果硝苯地平亲水凝胶骨架片的体外释药符合Higuchi动力学方程,体内外相关性方程为:Y=105.25R+20.894(r=0.9057),体内外相关性较好。结论自制亲水凝胶骨架缓释片具有较好的体内外相关性。
|
| 关 键 词： | 硝苯地平 体内外相关性 反卷积分法 |
Study on Correlation of Hydrophilic Gel Matrices Sustained-release Tablets of Nifedipine Between in vivo and in vitro |
| |
| CHEN Jun,YIN Wei. Study on Correlation of Hydrophilic Gel Matrices Sustained-release Tablets of Nifedipine Between in vivo and in vitro[J]. Medical and Health Care Instruments, 2012, 19(3): 345-347 |
| |
| Authors: | CHEN Jun YIN Wei |
| |
| Affiliation: | 1Department of Post Graduate, Nanjing University of TCM, Nanjing 210046, China; 2Department of Pharmacy, Xinghua college of Anhui, Hefei 230038, China) |
| |
| Abstract: | Objective To research the correlation of hydrophilic gel matrices sustained-release tablets of nifedipine between in vivo and in vitro. Methods The self-made hydrophilic gel matrices sustained-release tablets of nifedipine were used to investigate its release in vitro and the release process of rat in vivo. The in vivo-in vitro correlation was evaluated according to deconvolution technique. Results The release of hydrophilic gel matrices sustained-release tablets of nifedipine in vitro conformed to Higuchi equation; the correlation equation between in vivo and in vitro was: Y = 105.25R + 20.894 (r = 0.9057), which showed good correlation. Conclusions The self-made hydrophilic gel matrices sustained-release tablets of nifedipine have good correlation between in vivo and in vitro. |
| |
| Keywords: | Nifedipine Correlation between in vivo and in vitro Deconvolution technique |
| 本文献已被 CNKI 等数据库收录！ |
|
