婴幼儿抗生素相关性腹泻临床分析

目的：提高对头孢茵素在应用过程中导致婴幼儿抗生素相关性腹泻的认识,并探讨其防治方法。方法：随机选择呼吸道感染婴幼儿,分别应用头孢硫脒治疗200例,头孢呋辛188例,每日应用量均为50～100mg·kg·d~(-1),分两次静滴,疗程7～14 d,观察两组抗生素相关性腹泻发生率,进行统计学分析,探讨其发病原因,及防治办法。结果：两组婴幼儿抗生素相关性腹泻发病率分别为14%、22．3%,应用微生态制剂及肠粘膜保护药治疗腹泻,均取得满意疗效。结论：婴幼儿抗生素相关性腹泻发病率较高,与多种因素有关,可应用微生态制剂及肠粘膜保护药防治抗生素相关性腹泻。

Clinical Analysis of Antibiotic-related Diarrhea in Infants

Objective:To enhance the recognition of antibiotic-related diarrhea in infants and study the method of prevention and treatment.Method:382 infants with respiratory tract infections were chosen by random.200 cases of respir- atory tract infections were treated with cefathiamidine,and 182 cases,with cefuroxime,(500-1 000 mg with per kilo body weight,drop twice a day) for 7-14 days.The incidence rate of antibiotic-associated diarrhea was observed,and its statisti- cal analysis,made,the cause of morbidity,investigated,and the therapeutic efficacy,evvaluated.Result:The incidence rates of antibiotic-related diarrhea in the two groups were 14% and 20.9% respectively.The curative effect of diarrhea treated with ecosystem and bowel mueosa protective agents was satisfactory.Conclusion:The incidence rate of the antibiot- ic-related diarrhea in infants was high and was related with many factors.The ecosystem and bowel mucosa protective agents may prevent and cure the antibiotic-related diarrhea.