降低米非司酮和米索前列醇剂量催经止孕效果观察

目的：观察降低米非司酮与米索前列醇剂量催经止孕的临床效果。方法：将120例闭经时间≤37d的妇女随机分为2组（各60例）。低剂量组：给予米非司酮100mg口服,米索前列醇400μg舌下含服;常规剂量组：给予米非司酮150mg,米索前列醇600μg口服。比较给药后2组的完全流产率、出血时间、平均流产时间和不良反应的程度。结果：测定血清人绒毛膜促性腺激素β亚单位（β-hCG）诊断低剂量和常规剂量组分别有3例和2例未妊娠,给药后均引发阴道出血（即月经来潮）。2组完全流产率、出血时间差异无统计学意义（P〉0.05）;常规剂量组平均流产时间短于低剂量组（P〈0.05）;低剂量组不良反应发生率低于常规剂量组（P〈0.05）。结论：降低米非司酮和米索前列醇剂量用于闭经≤37d催经止孕可行,且不良反应少。

Study on Rreducing Dose of Mifepristone Combined with Misaprontol for Menstrual Regulation

Objective:To study clinical efficacy of lower dose of mifepristone combined with misoprostol.Methods:120 women with amenorrhea less than 37 days for 2 groups randomly.Sixty women in group of lower dosage(experimental group):these women were dosed with mifepristone 100 mg for oral taken and oral cavity misoprostol 0.4 mg for sublingual taken.Sixty women in group of conventional dosage(control group):these women were dosed with mifepristone 150 mg and misoprostol 0.6 mg for oral taken.Under the premise of red...