高危非致残性缺血性脑血管事件定义及预测模型

高危非致残性缺血性脑血管事件（high r isk n on-disabling ischemic cerebrovascular events， HR-NICE）患者处于不稳定状态，早期复发进展为严重卒中的风险较高。目前，不同的临床评分系统是 临床工作者常用的预测模型，但随着近些年对影像及分子标记物研究的深入，发现其同样能够预测 卒中复发风险，进而指导HR-NICE人群的早期干预及个体化治疗，从而改善患者预后、降低致残率， 同时可以降低国家卒中负担。本文根据近年对于卒中复发风险预测模型的相关研究，对HR-NICE的定 义、临床、影像和分子标记物研究进展进行综述，为临床工作者提供其预后评判参考。

Definition and Prediction Models for High-Risk Non-Disabling Ischemic Cerebrovascular Events

The patients who have high risk non-disabling ischemic cerebrovascular events are
in unstable state, and they have high risks of early recurrent stroke. At present, different clinical
scoring systems are widely used, with the development of the imaging and molecular biology, these
technology can be used to predict recurrent stroke risk, so that early intervention and individual
therapy can be provided for patients. It could improve prognosis and reduce the disability rate and
burden of stroke. This paper aims to discuss the definition of HR-NICE and predictors of clinical,
imaging and molecule for recurrent stroke prediction models according to recent studies, so as to
provide reference for clinical work.