脑梗死急性期患者脑血流自动调节功能观察

目的 利用临界关闭压（critical closing pressure，CCP）探讨脑梗死急性期自动调节功能及与病情的相关性。 

Autoregulation of Cerebral Blood Flow in Acute Cerebral Infarction and Its Relationship with Clinical Stroke Severity

Objective To explore the changes of autoregulation of cerebral blood flow in acute cerebral infarction
and its relationship with clinical stroke severity based on critical closing pressure (CCP) theory.
Methods All patients who had acute cerebral infarction within 3 days were detected by TCD and
continuous non-invasive blood pressure monitor on admission, recording the curves of blood flow
velocity of anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery
(PCA) and radial artery blood pressure, to work out the values of CCP of responsible arteries. National
Institutes of Health stroke scale (NIHSS) scores, modified Rankin scale (mRS) scores on admission
and mRS scores at 3 months were recorded. The changes of autoregulation of cerebral blood flow in
acute cerebral infarction group and its relationship with clinical stroke severity were evaluated.
Results There was no difference in the value of CCP between cerebral infarction group and health
control group. For regional responsible vessels in cerebral infarction group, the CCP of MCA was
correlative with NIHSS score on admission, and the CCP of PCA were correlative with NIHSS
score and mRS score on admission (r =0.536, 0.600, 0.518, P <0.05), but not associated with mRS
score at 3 months.
Conclusions The CCP values of responsible arteries in patients with acute cerebral infarction can
reflect the severity of stroke.